Phage major coat protein

Phage coat Gp8

Single subunit of coat protein
Identifiers
Symbol Phage_Coat_Gp8
Pfam PF05371
Pfam clan CL0371
InterPro IPR008020
SCOP 1fdm
SUPERFAMILY 1fdm
OPM superfamily 73
OPM protein 1ifk

In molecular biology, a phage major coat protein is an alpha-helical protein that forms a viral envelope of filamentous bacteriophages. These bacteriophages are flexible rods, about one to two micrometres long and six nm in diameter, with a helical shell of protein subunits surrounding a DNA core. The approximately 50-residue subunit of the major coat protein is largely alpha-helix, and the axis of the alpha-helix makes a small angle with the axis of the virion. The protein shell can be considered in three sections: the outer surface, occupied by the N-terminal region of the subunit and rich in acidic residues that give the virion a low isoelectric point; the interior of the shell (including a 19-residue stretch of apolar side-chains) where protein subunits interact, mainly with each other; and the inner surface (occupied by the C-terminal region of the subunit), rich in positively charged residues that interact with the DNA core.[1]

References

  1. Marvin DA, Hale RD, Nave C, Helmer-Citterich M (January 1994). "Molecular models and structural comparisons of native and mutant class I filamentous bacteriophages Ff (fd, f1, M13), If1 and IKe". J. Mol. Biol. 235 (1): 260–86. doi:10.1016/S0022-2836(05)80032-4. PMID 8289247.

This article incorporates text from the public domain Pfam and InterPro IPR008020

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