Peptide-methionine (S)-S-oxide reductase

Peptide-methionine (S)-S-oxide reductase
Identifiers
EC number 1.8.4.11
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Peptide-methionine (S)-S-oxide reductase (EC 1.8.4.11, MsrA, methionine sulphoxide reductase A, methionine S-oxide reductase (S-form oxidizing), methionine sulfoxide reductase A, peptide methionine sulfoxide reductase) is an enzyme with systematic name peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase (L-methionine (S)-S-oxide-forming).[1][2][3][4][5][6][7][8][9][10] This enzyme catalyses the following chemical reaction

(1) peptide-L-methionine + thioredoxin disulfide + H2O peptide-L-methionine (S)-S-oxide + thioredoxin
(2) L-methionine + thioredoxin disulfide + H2O L-methionine (S)-S-oxide + thioredoxin

The reaction occurs in the reverse direction.

References

  1. ↑ Moskovitz, J.; Singh, V.K.; Requena, J.; Wilkinson, B.J.; Jayaswal, R.K.; Stadtman, E.R. (2002). "Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity". Biochem. Biophys. Res. Commun. 290: 62–65. doi:10.1006/bbrc.2001.6171. PMID 11779133.
  2. ↑ Taylor, A.B.; Benglis, D.M.; Jr.; Dhandayuthapani, S.; Hart, P.J. (2003). "Structure of Mycobacterium tuberculosis methionine sulfoxide reductase A in complex with protein-bound methionine". J. Bacteriol. 185: 4119–4126. doi:10.1128/JB.185.14.4119-4126.2003. PMC 164888Freely accessible. PMID 12837786.
  3. ↑ Singh, V.K.; Moskovitz, J. (2003). "Multiple methionine sulfoxide reductase genes in Staphylococcus aureus: expression of activity and roles in tolerance of oxidative stress". Microbiology. 149: 2739–2747. doi:10.1099/mic.0.26442-0. PMID 14523107.
  4. ↑ Boschi-Muller, S.; Olry, A.; Antoine, M.; Branlant, G. (2005). "The enzymology and biochemistry of methionine sulfoxide reductases". Biochim. Biophys. Acta. 1703: 231–238. doi:10.1016/j.bbapap.2004.09.016. PMID 15680231.
  5. ↑ Ezraty, B.; Aussel, L.; Barras, F. (2005). "Methionine sulfoxide reductases in prokaryotes". Biochim. Biophys. Acta. 1703: 221–229. doi:10.1016/j.bbapap.2004.08.017. PMID 15680230.
  6. ↑ Weissbach, H.; Resnick, L.; Brot, N. (2005). "Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage". Biochim. Biophys. Acta. 1703: 203–212. doi:10.1016/j.bbapap.2004.10.004. PMID 15680228.
  7. ↑ Kauffmann, B.; Aubry, A.; Favier, F. (2005). "The three-dimensional structures of peptide methionine sulfoxide reductases: current knowledge and open questions". Biochim. Biophys. Acta. 1703: 249–260. doi:10.1016/j.bbapap.2004.09.008. PMID 15680233.
  8. ↑ Vougier, S.; Mary, J.; Friguet, B. (2003). "Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells". Biochem. J. 373: 531–537. doi:10.1042/BJ20030443. PMC 1223498Freely accessible. PMID 12693988.
  9. ↑ Olry, A.; Boschi-Muller, S.; Marraud, M.; Sanglier-Cianferani, S.; Van Dorsselear, A.; Branlant, G. (2002). "Characterization of the methionine sulfoxide reductase activities of PILB, a probable virulence factor from Neisseria meningitidis". J. Biol. Chem. 277: 12016–12022. doi:10.1074/jbc.M112350200. PMID 11812798.
  10. ↑ Brot, N.; Weissbach, L.; Werth, J.; Weissbach, H. (1981). "Enzymatic reduction of protein-bound methionine sulfoxide". Proc. Natl. Acad. Sci. USA. 78 (4): 2155–2158. doi:10.1073/pnas.78.4.2155. PMC 319302Freely accessible. PMID 7017726.
This article is issued from Wikipedia - version of the 5/22/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.