PTRF

PTRF
Identifiers
Aliases PTRF, CAVIN, CAVIN1, CGL4, cavin-1, FKSG13, polymerase I and transcript release factor
External IDs MGI: 1277968 HomoloGene: 7499 GeneCards: PTRF
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

284119

19285

Ensembl

ENSG00000177469

ENSMUSG00000004044

UniProt

Q6NZI2

O54724

RefSeq (mRNA)

NM_012232

NM_008986

RefSeq (protein)

NP_036364.2

NP_033012.1

Location (UCSC) Chr 17: 42.4 – 42.42 Mb Chr 11: 100.96 – 100.97 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Polymerase I and transcript release factor, also known as PTRF, is a protein which in humans is encoded by the PTRF gene.[3]

Function

Termination of RNA polymerase I catalyzed transcription is a 2-step process that involves pausing of transcription elongation and release of both the pre-ribosomal RNA and Pol I from the DNA template. The pausing is mediated by TTF1 and PTRF.[4][5]

PTRF is a soluble protein containing putative leucine zipper, nuclear localization signal, and PEST domains.[6]

Interactions

PTRF has been shown to interact with ZNF148.[7]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. "Entrez Gene: PTRF polymerase I and transcript release factor".
  4. Mason SW, Sander EE, Grummt I (January 1997). "Identification of a transcript release activity acting on ternary transcription complexes containing murine RNA polymerase I". The EMBO Journal. 16 (1): 163–72. doi:10.1093/emboj/16.1.163. PMC 1169623Freely accessible. PMID 9009277.
  5. Jansa P, Mason SW, Hoffmann-Rohrer U, Grummt I (May 1998). "Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes". The EMBO Journal. 17 (10): 2855–64. doi:10.1093/emboj/17.10.2855. PMC 1170626Freely accessible. PMID 9582279.
  6. Aboulaich N, Vainonen JP, Strålfors P, Vener AV (October 2004). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes". The Biochemical Journal. 383 (Pt 2): 237–48. doi:10.1042/BJ20040647. PMC 1134064Freely accessible. PMID 15242332.
  7. Hasegawa, T; Takeuchi A; Miyaishi O; Xiao H; Mao J; Isobe K (April 2000). "PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters". Biochem. J. ENGLAND. 347 Pt 1 (Pt 1): 55–9. doi:10.1042/0264-6021:3470055. ISSN 0264-6021. PMC 1220930Freely accessible. PMID 10727401.

Further reading


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