PRINS (gene)
| PRINS | ||||||
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| Aliases | PRINS, NCRNA00074, psoriasis associated non-protein coding RNA induced by stress | |||||
| External IDs | GeneCards: PRINS | |||||
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| Species | Human | Mouse | ||||
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| Location (UCSC) | n/a | n/a | ||||
| PubMed search | [1] | n/a | ||||
| Wikidata | ||||||
| View/Edit Human | |||
PRINS (psoriasis associated RNA induced by stress) is a long non-coding RNA. Its expression is induced by stress, and it may have a protective role in cells exposed to stress. It is over-expressed in the skin of patients with psoriasis.[2] It regulates G1P3, a gene encoding a protein with anti-apoptotic effects in keratinocytes. Overexpression of PRINS may contribute to psoriasis via the down-regulation of G1P3.[3]
See also
References
- ↑ "Human PubMed Reference:".
- ↑ Sonkoly E, Bata-Csorgo Z, Pivarcsi A, et al. (June 2005). "Identification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS". J. Biol. Chem. 280 (25): 24159–67. doi:10.1074/jbc.M501704200. PMID 15855153.
- ↑ Szegedi K, Sonkoly E, Nagy N, et al. (March 2010). "The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA, PRINS". Exp. Dermatol. 19 (3): 269–78. doi:10.1111/j.1600-0625.2010.01066.x. PMID 20377629.
Further reading
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
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