PKP3

PKP3
Identifiers
Aliases PKP3
External IDs MGI: 1891830 HomoloGene: 5200 GeneCards: PKP3
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

11187

56460

Ensembl

ENSG00000184363

ENSMUSG00000054065

UniProt

Q9Y446

Q9QY23

RefSeq (mRNA)

NM_007183
NM_001303029

NM_001162924
NM_019762

RefSeq (protein)

NP_001289958.1
NP_009114.1

NP_001156396.1
NP_062736.2

Location (UCSC) Chr 11: 0.39 – 0.4 Mb Chr 7: 141.08 – 141.09 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Plakophilin-3 is a protein that in humans is encoded by the PKP3 gene.[3][4]

Function

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways.[4]

Interactions

PKP3 has been shown to interact with:

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Schmidt A, Langbein L, Prätzel S, Rode M, Rackwitz HR, Franke WW (Jun 1999). "Plakophilin 3--a novel cell-type-specific desmosomal plaque protein". Differentiation. 64 (5): 291–306. doi:10.1046/j.1432-0436.1999.6450291.x. PMID 10374265.
  4. 1 2 "Entrez Gene: PKP3 plakophilin 3".
  5. 1 2 3 4 Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (Apr 2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. PMC 2172904Freely accessible. PMID 12707304.

Further reading


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