PILRB

PILRB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases PILRB, FDFACT1, FDFACT2, paired immunoglobin-like type 2 receptor beta
External IDs MGI: 2450532 HomoloGene: 114502 GeneCards: PILRB
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

29990

170741

Ensembl

ENSG00000121716

ENSMUSG00000066684

UniProt

Q9UKJ0

Q2YFS2

RefSeq (mRNA)

NM_178238
NM_013440
NM_175047

NM_133209

RefSeq (protein)

NP_839956.1

NP_573472.2

Location (UCSC) Chr 7: 100.35 – 100.37 Mb Chr 5: 137.85 – 137.86 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Paired immunoglobulin-like type 2 receptor beta is a protein that in humans is encoded by the PILRB gene.[3][4]

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role. Alternative splicing has been observed at this locus and three variants, encoding two distinct isoforms, are described. Additional transcript variants have been identified but their full-length nature has not been determined.[4]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Mousseau DD, Banville D, L'Abbe D, Bouchard P, Shen SH (Mar 2000). "PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta". J Biol Chem. 275 (6): 4467–74. doi:10.1074/jbc.275.6.4467. PMID 10660620.
  4. 1 2 "Entrez Gene: PILRB paired immunoglobin-like type 2 receptor beta".

Further reading


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