Oltipraz
Clinical data | |
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ATC code | none |
Identifiers | |
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CAS Number | 64224-21-1 |
PubChem (CID) | 47318 |
ChemSpider | 43066 |
UNII | 6N510JUL1Y |
ChEBI | CHEBI:77319 |
ChEMBL | CHEMBL178459 |
ECHA InfoCard | 100.058.833 |
Chemical and physical data | |
Formula | C8H6N2S3 |
Molar mass | 226.34 g/mol |
3D model (Jmol) | Interactive image |
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Oltipraz is an organosulfur compound belonging to the dithiolethione class.[1] It acts as a schistosomicide and has been shown in rodent models to inhibit the formation of cancers in the bladder, blood, colon, kidney, liver, lung, pancreas, stomach, and trachea, skin, and mammary tissue.[2][3] Clinical trials of oltipraz have failed to demonstrate efficacy and have shown significant side effects, including neurotoxicity and gastrointestinal toxicity.[2] Oltipraz has also been shown to generate superoxide radical, which can be toxic.[4]
References
- ↑ Prince M, Li Y, Childers A, Itoh K, Yamamoto M, Kleiner HE (March 2009). "Comparison of citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice". Toxicol. Lett. 185 (3): 180–6. doi:10.1016/j.toxlet.2008.12.014. PMC 2676710. PMID 19150646.
- 1 2 Zhang Y, Gordon GB (July 2004). "A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway". Mol. Cancer Ther. 3 (7): 885–93. PMID 15252150.
- ↑ Iida K, Itoh K, Kumagai Y, et al. (September 2004). "Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis". Cancer Res. 64 (18): 6424–31. doi:10.1158/0008-5472.CAN-04-1906. PMID 15374950.
- ↑ Velayutham M, Villamena FA, Fishbein JC, Zweier JL (March 2005). "Cancer chemopreventive oltipraz generates superoxide anion radical". Arch. Biochem. Biophys. 435 (1): 83–8. doi:10.1016/j.abb.2004.11.028. PMID 15680910.
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