OS9 (gene)

OS9
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases OS9, ERLEC2, OS-9, endoplasmic reticulum lectin
External IDs MGI: 1924301 HomoloGene: 31409 GeneCards: OS9
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

10956

216440

Ensembl

ENSG00000135506

ENSMUSG00000040462

UniProt

Q13438

Q8K2C7

RefSeq (mRNA)

NM_001171026
NM_177614

RefSeq (protein)

NP_001164497.1
NP_808282.2

Location (UCSC) Chr 12: 57.69 – 57.72 Mb Chr 10: 127.09 – 127.12 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Protein OS-9 is a protein that in humans is encoded by the OS9 gene.[3][4][5][6][7]

Function

This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[7]

Model organisms

Model organisms have been used in the study of OS9 function. A conditional knockout mouse line called Os9tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[8] Male and female animals underwent a standardized phenotypic screen[9] to determine the effects of deletion.[10][11][12][13] Additional screens performed: - In-depth immunological phenotyping[14]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Su YA, Hutter CM, Trent JM, Meltzer PS (Apr 1996). "Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas". Molecular Carcinogenesis. 15 (4): 270–5. doi:10.1002/(SICI)1098-2744(199604)15:4<270::AID-MC4>3.0.CO;2-K. PMID 8634085.
  4. ↑ Kimura Y, Nakazawa M, Tsuchiya N, Asakawa S, Shimizu N, Yamada M (Dec 1997). "Genomic organization of the OS-9 gene amplified in human sarcomas". Journal of Biochemistry. 122 (6): 1190–5. doi:10.1093/oxfordjournals.jbchem.a021880. PMID 9498564.
  5. ↑ Hosokawa N, Kamiya Y, Kamiya D, Kato K, Nagata K (Jun 2009). "Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans". The Journal of Biological Chemistry. 284 (25): 17061–8. doi:10.1074/jbc.M809725200. PMC 2719344Freely accessible. PMID 19346256.
  6. ↑ Christianson JC, Shaler TA, Tyler RE, Kopito RR (Mar 2008). "OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD". Nature Cell Biology. 10 (3): 272–82. doi:10.1038/ncb1689. PMC 2757077Freely accessible. PMID 18264092.
  7. 1 2 "Entrez Gene: OS9 amplified in osteosarcoma".
  8. ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  9. 1 2 "International Mouse Phenotyping Consortium".
  10. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410Freely accessible. PMID 21677750.
  11. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  12. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  13. ↑ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207Freely accessible. PMID 23870131.
  14. 1 2 "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129Freely accessible. PMID 16344560. 
  • Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL (Feb 2005). "OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha". Molecular Cell. 17 (4): 503–12. doi:10.1016/j.molcel.2005.01.011. PMID 15721254. 
  • Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148Freely accessible. PMID 15231748. 
  • Vigneron N, Ooms A, Morel S, Degiovanni G, Van Den Eynde BJ (Jul 2002). "Identification of a new peptide recognized by autologous cytolytic T lymphocytes on a human melanoma". Cancer Immunity. 2: 9. PMID 12747754. 
  • Litovchick L, Friedmann E, Shaltiel S (Sep 2002). "A selective interaction between OS-9 and the carboxyl-terminal tail of meprin beta". The Journal of Biological Chemistry. 277 (37): 34413–23. doi:10.1074/jbc.M203986200. PMID 12093806. 
  • Friedmann E, Salzberg Y, Weinberger A, Shaltiel S, Gerst JE (Sep 2002). "YOS9, the putative yeast homolog of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins". The Journal of Biological Chemistry. 277 (38): 35274–81. doi:10.1074/jbc.M201044200. PMID 12077121. 
  • Nakayama T, Yaoi T, Kuwajima G, Yoshie O, Sakata T (Jun 1999). "Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma". FEBS Letters. 453 (1-2): 77–80. doi:10.1016/S0014-5793(99)00700-0. PMID 10403379. 
  • Kimura Y, Nakazawa M, Yamada M (May 1998). "Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines". Journal of Biochemistry. 123 (5): 876–82. doi:10.1093/oxfordjournals.jbchem.a022019. PMID 9562620. 
  • Elkahloun AG, Krizman DB, Wang Z, Hofmann TA, Roe B, Meltzer PS (Jun 1997). "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers". Genomics. 42 (2): 295–301. doi:10.1006/geno.1997.4727. PMID 9192850. 
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