Phorbol-12-myristate-13-acetate-induced protein 1

PMAIP1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3MQP
Identifiers
Aliases	PMAIP1, APR, NOXA, phorbol-12-myristate-13-acetate-induced protein 1
External IDs	OMIM: 604959 HomoloGene: 88883 GeneCards: PMAIP1
Gene ontology Molecular function • protein binding Cellular component • cytosol • mitochondrial outer membrane • mitochondrion • nucleus Biological process • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors • response to dsRNA • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • cellular response to glucose starvation • positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • negative regulation of mitochondrial membrane potential • positive regulation of glucose metabolic process • reactive oxygen species metabolic process • cellular response to DNA damage stimulus • T cell homeostasis • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of neuron apoptotic process • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • regulation of mitochondrial membrane permeability • defense response to virus • intrinsic apoptotic signaling pathway by p53 class mediator • intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of protein oligomerization • positive regulation of apoptotic process • positive regulation of release of cytochrome c from mitochondria • proteasomal protein catabolic process • positive regulation of DNA damage response, signal transduction by p53 class mediator • activation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of fibroblast proliferation • positive regulation of intrinsic apoptotic signaling pathway • response to UV • cellular response to hypoxia • response to X-ray • release of cytochrome c from mitochondria • intrinsic apoptotic signaling pathway • apoptotic process • regulation of apoptotic process • protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5366	n/a
Ensembl	ENSG00000141682	n/a
UniProt	Q13794	n/a
RefSeq (mRNA)	NM_021127	n/a
RefSeq (protein)	NP_066950.1	n/a
Location (UCSC)	Chr 18: 59.9 – 59.9 Mb	n/a
PubMed search	[1]	n/a
Wikidata

Phorbol-12-myristate-13-acetate-induced protein 1 is a protein that in humans is encoded by the PMAIP1 gene, and is also known as Noxa.^[2][3][4]

Noxa (Latin for damage) is a pro-apoptotic member of the Bcl-2 protein family.^[5] Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of Noxa is regulated by the tumor suppressor p53, and Noxa has been shown to be involved in p53-mediated apoptosis.

Interactions

Noxa has been shown to interact with:

• BCL2-like 1,^[6][7]
• Bcl-2,^[6][7] and
• MCL1.^[6][8]

See also

• Apoptosis
• Apoptosome
• Bcl-2
• Bcl-2-associated X protein (BAX)
• BH3 interacting domain death agonist (BID)
• Caspases
• Cytochrome c
• Mitochondrion
• p53 upregulated modulator of apoptosis (PUMA)
• 12-O-Tetradecanoylphorbol-13-acetate (Phorbol-12-myristate-13-acetate)

References

Further reading

External links

• NOXA protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)