Non-cirrhotic portal fibrosis

Non-cirrhotic portal fibrosis (NCPF) is a chronic liver disease[1] and type of non-cirrhotic portal hypertension (NCPH). It is characterized by 'obliterative portovenopathy', which leads to various problems such as portal hypertension, massive splenomegaly, and variceal bleeding. It is estimated that about 85% of people with NCPF have repeated episodes of variceal bleeding.[2]Hallmark of the disease is thrombosis/sclerosis of portal vein branches.Vessels formed are often termed as mesangiosinusoids or periportal cavernoma.

Prevalence

This disease has been reported to affect people all over the world. It has been found to exist in about 3–5% of people with NCPH.[3]

References

  1. ↑ Non-cirrhotic portal fibrosis: one disease with many names? An analysis from morphological study of native explant livers with end stage chronic liver disease -- Nayak et al 64(7): 592 -- Journal of Clinical Pathology
  2. ↑ Non-cirhotic portal fibrosis. [J Gastroenterol Hepatol. 2002] - PubMed - NCBI
  3. ↑ Internet Scientific Publications


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