Naphthylvinylpyridine
 | |
| Names | |
|---|---|
| IUPAC name
4-[(E)-2-naphthalen-1-ylethenyl]pyridine | |
| Identifiers | |
16375-56-7  | |
| 3D model (Jmol) | Interactive image |
| ECHA InfoCard | 100.203.347 |
| PubChem | 5475238 |
| |
| Properties | |
| C17H13N | |
| Molar mass | 231.29 g/mol |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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| Infobox references | |
Naphthylvinylpyridine (NVP) is a naphthalene derivative that possesses anticholinergic activity similar to that of atropine. However, NVP's method of acetylcholine (ACh) antagonism involves inhibiting the enzyme choline acetyltransferase.[1]
Several NVP derivatives have been synthesized and evaluated for their ability to inhibit choline acetyltransferase and protect against nerve toxins.[2][3]
References
- ↑ Haubrich, DR; Goldberg, ME (1975). "Homovanillic acid concentration in the rat brain: Effect of a choline acetyltransferase inhibitor and comparison with cholinergic and dopaminergic agents". Neuropharmacology. Squibb Institute for Medical Research. 14 (3): 211–214. doi:10.1016/0028-3908(75)90007-6. PMID 1134625. Retrieved July 2011. Check date values in:
|access-date=(help) - ↑ Cozzari, Costantino; Hartman, BK (1983). "Synthesis of a naphthylvinylpyridine derivative and its use for affinity chromatography of choline acetyltransferase". Analytical Biochemistry. Department of Psychiatry and Neurobiology, Washington University School of Medicine. 133 (1): 120–125. doi:10.1016/0003-2697(83)90231-2. Retrieved July 2011. Check date values in:
|access-date=(help) - ↑ Gray, AP; Henderson, TR (1988). "Approaches to protection against nerve agent poisoning". J Med Chem. Dynamac Corporation. 31 (4): 807–814. doi:10.1021/jm00399a022. PMID 3351860.
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