NVL (gene)

NVL

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2X8A

Identifiers

NVL, NVL2, nuclear VCP-like

External IDs

MGI: 1914709 HomoloGene: 1902 GeneCards: NVL

Gene ontology
Molecular function	• nucleotide binding • poly(A) RNA binding • preribosome binding • protein binding • ATP binding
Cellular component	• nucleolus • membrane • mitochondrion • nucleus • telomerase holoenzyme complex • nucleoplasm
Biological process	• ribosome biogenesis • positive regulation of telomerase activity
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


4931


67459


ENSG00000143748


ENSMUSG00000026516


O15381


Q9DBY8

RefSeq (mRNA)


NM_001243146 NM_001243147 NM_002533 NM_206840


NM_026171

RefSeq (protein)


NP_001230075.1 NP_001230076.1 NP_002524.2 NP_996671.1


NP_080447.1

Location (UCSC)

Chr 1: 224.23 – 224.33 Mb

Chr 1: 181.09 – 181.14 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Nuclear valosin-containing protein-like is a protein that in humans is encoded by the NVL gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Germain-Lee EL, Obie C, Valle D (Nov 1997). "NVL: a new member of the AAA family of ATPases localized to the nucleus". Genomics. 44 (1): 22–34. doi:10.1006/geno.1997.4856. PMID 9286697.
↑ "Entrez Gene: NVL nuclear VCP-like".

Further reading

Nagahama M, Yamazoe T, Hara Y, et al. (2006). "The AAA-ATPase NVL2 is a component of pre-ribosomal particles that interacts with the DExD/H-box RNA helicase DOB1.". Biochem. Biophys. Res. Commun. 346 (3): 1075–82. doi:10.1016/j.bbrc.2006.06.017. PMID 16782053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nagahama M, Hara Y, Seki A, et al. (2005). "NVL2 Is a Nucleolar AAA-ATPase that Interacts with Ribosomal Protein L5 through Its Nucleolar Localization Sequence". Mol. Biol. Cell. 15 (12): 5712–23. doi:10.1091/mbc.E04-08-0692. PMC 532049. PMID 15469983.
Leonard D, Ajuh P, Lamond AI, Legerski RJ (2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochem. Biophys. Res. Commun. 308 (4): 793–801. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

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