NARS (gene)

NARS
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases NARS, ASNRS, NARS1, asparaginyl-tRNA synthetase
External IDs MGI: 1917473 HomoloGene: 68404 GeneCards: NARS
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

4677

70223

Ensembl

ENSG00000134440

ENSMUSG00000024587

UniProt

O43776

Q8BP47

RefSeq (mRNA)

NM_004539

NM_001142950
NM_027350

RefSeq (protein)

NP_004530.1

NP_001136422.1
NP_081626.2

Location (UCSC) Chr 18: 57.6 – 57.62 Mb Chr 18: 64.5 – 64.52 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Asparaginyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the NARS gene.[3][4][5]

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases.[5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Cirullo RE, Arredondo-Vega FX, Smith M, Wasmuth JJ (May 1983). "Isolation and characterization of interspecific heat-resistant hybrids between a temperature-sensitive chinese hamster cell asparaginyl-tRNA synthetase mutant and normal human leukocytes: assignment of human asnS gene to chromosome 18". Somatic Cell Genet. 9 (2): 215–33. doi:10.1007/BF01543178. PMID 6836455.
  4. Beaulande M, Tarbouriech N, Hartlein M (Feb 1998). "Human cytosolic asparaginyl-tRNA synthetase: cDNA sequence, functional expression in Escherichia coli and characterization as human autoantigen". Nucleic Acids Res. 26 (2): 521–4. doi:10.1093/nar/26.2.521. PMC 147268Freely accessible. PMID 9421509.
  5. 1 2 "Entrez Gene: NARS asparaginyl-tRNA synthetase".

Further reading


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