NAGA (gene)
| NAGA | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 |
|||||||||||||||
| |||||||||||||||
| Identifiers | |||||||||||||||
| Aliases | NAGA, D22S674, GALB, alpha-N-acetylgalactosaminidase | ||||||||||||||
| External IDs | MGI: 1261422 HomoloGene: 221 GeneCards: NAGA | ||||||||||||||
| RNA expression pattern | |||||||||||||||
  | |||||||||||||||
| More reference expression data | |||||||||||||||
| Orthologs | |||||||||||||||
| Species | Human | Mouse | |||||||||||||
| Entrez | |||||||||||||||
| Ensembl | |||||||||||||||
| UniProt | |||||||||||||||
| RefSeq (mRNA) | |||||||||||||||
| RefSeq (protein) | |||||||||||||||
| Location (UCSC) | Chr 22: 42.06 – 42.07 Mb | Chr 15: 82.33 – 82.34 Mb | |||||||||||||
| PubMed search | [1] | [2] | |||||||||||||
| Wikidata | |||||||||||||||
| View/Edit Human | View/Edit Mouse |
Alpha-N-acetylgalactosaminidase is an enzyme that in humans is encoded by the NAGA gene.[3]
NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. Mutations in NAGA have been identified as the cause of Schindler disease types I and II (type II also known as Kanzaki disease).[3]
References
Further reading
- Cantz M, Ulrich-Bott B (1990). "Disorders of glycoprotein degradation.". J. Inherit. Metab. Dis. 13 (4): 523–37. doi:10.1007/BF01799510. PMID 2122119.
- Wang AM, Desnick RJ (1991). "Structural organization and complete sequence of the human alpha-N-acetylgalactosaminidase gene: homology with the alpha-galactosidase A gene provides evidence for evolution from a common ancestral gene.". Genomics. 10 (1): 133–42. doi:10.1016/0888-7543(91)90493-X. PMID 1646157.
- Wang AM, Bishop DF, Desnick RJ (1991). "Human alpha-N-acetylgalactosaminidase-molecular cloning, nucleotide sequence, and expression of a full-length cDNA. Homology with human alpha-galactosidase A suggests evolution from a common ancestral gene.". J. Biol. Chem. 265 (35): 21859–66. PMID 2174888.
- Wang AM, Schindler D, Desnick R (1990). "Schindler disease: the molecular lesion in the alpha-N-acetylgalactosaminidase gene that causes an infantile neuroaxonal dystrophy.". J. Clin. Invest. 86 (5): 1752–6. doi:10.1172/JCI114901. PMC 296929
. PMID 2243144. - Warner TG, Louie A, Potier M (1991). "Photolabeling of the alpha-neuraminidase/beta-galactosidase complex from human placenta with a photoreactive neuraminidase inhibitor.". Biochem. Biophys. Res. Commun. 173 (1): 13–9. doi:10.1016/S0006-291X(05)81014-9. PMID 2256909.
- Yamauchi T, Hiraiwa M, Kobayashi H, et al. (1990). "Molecular cloning of two species of cDNAs for human alpha-N-acetylgalactosaminidase and expression in mammalian cells.". Biochem. Biophys. Res. Commun. 170 (1): 231–7. doi:10.1016/0006-291X(90)91264-S. PMID 2372288.
- Tsuji S, Yamauchi T, Hiraiwa M, et al. (1989). "Molecular cloning of a full-length cDNA for human alpha-N-acetylgalactosaminidase (alpha-galactosidase B).". Biochem. Biophys. Res. Commun. 163 (3): 1498–504. doi:10.1016/0006-291X(89)91149-2. PMID 2551294.
- Chabás A, Coll MJ, Aparicio M, Rodriguez Diaz E (1995). "Mild phenotypic expression of alpha-N-acetylgalactosaminidase deficiency in two adult siblings.". J. Inherit. Metab. Dis. 17 (6): 724–31. doi:10.1007/BF00712015. PMID 7707696.
- Wang AM, Kanzaki T, Desnick RJ (1994). "The molecular lesion in the alpha-N-acetylgalactosaminidase gene that causes angiokeratoma corporis diffusum with glycopeptiduria.". J. Clin. Invest. 94 (2): 839–45. doi:10.1172/JCI117404. PMC 296165. PMID 8040340.
- de Jong J, van den Berg C, Wijburg H, et al. (1994). "alpha-N-acetylgalactosaminidase deficiency with mild clinical manifestations and difficult biochemical diagnosis.". J. Pediatr. 125 (3): 385–91. doi:10.1016/S0022-3476(05)83281-0. PMID 8071745.
- Keulemans JL, Reuser AJ, Kroos MA, et al. (1996). "Human alpha-N-acetylgalactosaminidase (alpha-NAGA) deficiency: new mutations and the paradox between genotype and phenotype.". J. Med. Genet. 33 (6): 458–64. doi:10.1136/jmg.33.6.458. PMC 1050630. PMID 8782044.
- Den Tandt WR, Scharpé S (1997). "Micromethod for the fluorimetric determination of plasma N-acetyl-alpha-D-galactosaminidase and study of some of its characteristics.". Enzyme Protein. 49 (5–6): 273–80. PMID 9252785.
- Gaudet R, Savage JR, McLaughlin JN, et al. (1999). "A molecular mechanism for the phosphorylation-dependent regulation of heterotrimeric G proteins by phosducin". Mol. Cell. 3 (5): 649–60. doi:10.1016/S1097-2765(00)80358-5. PMID 10360181.
- Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- Ohta M, Ohnishi T, Ioannou YA, et al. (2000). "Human alpha-N-acetylgalactosaminidase: site occupancy and structure of N-linked oligosaccharides". Glycobiology. 10 (3): 251–61. doi:10.1093/glycob/10.3.251. PMID 10704524.
- Kodama K, Kobayashi H, Abe R, et al. (2001). "A new case of alpha-N-acetylgalactosaminidase deficiency with angiokeratoma corporis diffusum, with Ménière's syndrome and without mental retardation". Br. J. Dermatol. 144 (2): 363–8. doi:10.1046/j.1365-2133.2001.04028.x. PMID 11251574.
- Mohamad SB, Nagasawa H, Uto Y, Hori H (2003). "Tumor cell alpha-N-acetylgalactosaminidase activity and its involvement in GcMAF-related macrophage activation". Comp. Biochem. Physiol., Part a Mol. Integr. Physiol. 132 (1): 1–8. doi:10.1016/S1095-6433(01)00522-0. PMID 12062184.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
This article is issued from Wikipedia - version of the 6/3/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.