CHRNA9
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Neuronal acetylcholine receptor subunit alpha-9 is a protein that in humans is encoded by the CHRNA9 gene.[4]
This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. The protein is additionally expressed in keratinocytes, the pituitary gland, B-cells and T-cells.[4]
Selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.[5]
See also
References
- ↑ "Drugs that physically interact with Neuronal acetylcholine receptor subunit alpha-9 view/edit references on wikidata".
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- 1 2 "Entrez Gene: CHRNA9 cholinergic receptor, nicotinic, alpha 9".
- ↑ Vincler M, Wittenauer S, Parker R, Ellison M, Olivera BM, McIntosh JM (November 2006). "Molecular mechanism for analgesia involving specific antagonism of α9α10 nicotinic acetylcholine receptors". Proc. Natl. Acad. Sci. U.S.A. 103 (47): 17880–4. doi:10.1073/pnas.0608715103. PMC 1635975
. PMID 17101979.
Further reading
- Nguyen VT, Ndoye A, Grando SA (2000). "Novel Human α9 Acetylcholine Receptor Regulating Keratinocyte Adhesion is Targeted by Pemphigus Vulgaris Autoimmunity". Am. J. Pathol. 157 (4): 1377–91. doi:10.1016/S0002-9440(10)64651-2. PMC 1850172. PMID 11021840.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Sgard F, Charpantier E, Bertrand S, et al. (2002). "A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit". Mol. Pharmacol. 61 (1): 150–9. doi:10.1124/mol.61.1.150. PMID 11752216.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lustig LR, Peng H (2003). "Chromosome location and characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) gene". Cytogenet. Genome Res. 98 (2–3): 154–9. doi:10.1159/000069804. PMID 12697997.
- Valor LM, Castillo M, Ortiz JA, Criado M (2003). "Transcriptional regulation by activation and repression elements located at the 5'-noncoding region of the human alpha9 nicotinic receptor subunit gene". J. Biol. Chem. 278 (39): 37249–55. doi:10.1074/jbc.M307043200. PMID 12860975.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Peng H, Ferris RL, Matthews T, et al. (2004). "Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes". Life Sci. 76 (3): 263–80. doi:10.1016/j.lfs.2004.05.031. PMID 15531379.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
- Chernyavsky AI, Arredondo J, Vetter DE, Grando SA (2007). "CENTRAL ROLE OF α9 ACETYLCHOLINE RECEPTOR IN COORDINATING KERATINOCYTE ADHESION AND MOTILITY AT THE INITIATION OF EPITHELIALIZATION". Exp. Cell Res. 313 (16): 3542–55. doi:10.1016/j.yexcr.2007.07.011. PMC 2682983. PMID 17706194.
External links
- CHRNA9 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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