N-acetylphosphatidylethanolamine-hydrolysing phospholipase D
N-acetylphosphatidylethanolamine-hydrolysing phospholipase D | |||||||||
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Identifiers | |||||||||
EC number | 3.1.4.54 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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N-acetylphosphatidylethanolamine-hydrolysing phospholipase D (EC 3.1.4.54, NAPE-PLD, anandamide-generating phospholipase D, N-acyl phosphatidylethanolamine phospholipase D, NAPE-hydrolyzing phospholipase D) is an enzyme with systematic name N-acetylphosphatidylethanolamine phosphatidohydrolase.[1][2] This enzyme catalyses the following chemical reaction
- N-acylphosphatidylethanolamine + H2O N-acylethanolamine + a 1,2-diacylglycerol 3-phosphate
This enzyme is involved in the biosynthesis of anandamide.
References
- ↑ Okamoto, Y.; Morishita, J.; Tsuboi, K.; Tonai, T.; Ueda, N. (2004). "Molecular characterization of a phospholipase D generating anandamide and its congeners". J. Biol. Chem. 279 (7): 5298–5305. doi:10.1074/jbc.M306642200. PMID 14634025.
- ↑ Wang, J.; Okamoto, Y.; Morishita, J.; Tsuboi, K.; Miyatake, A.; Ueda, N. (2006). "Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-β-lactamase family". J. Biol. Chem. 281 (18): 12325–12335. doi:10.1074/jbc.M512359200. PMID 16527816.
External links
- N-acetylphosphatidylethanolamine-hydrolysing phospholipase D at the US National Library of Medicine Medical Subject Headings (MeSH)
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