NANS

NANS
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1WVO
Identifiers
Aliases	NANS, HEL-S-100, SAS, N-acetylneuraminate synthase, SEMDG
External IDs	MGI: 2149820 HomoloGene: 10343 GeneCards: NANS
EC number	2.5.1.57
Gene ontology Molecular function • N-acetylneuraminate synthase activity • transferase activity • catalytic activity • N-acylneuraminate cytidylyltransferase activity • N-acylneuraminate-9-phosphate synthase activity Cellular component • cytoplasm • cytosol • extracellular exosome Biological process • carbohydrate biosynthetic process • lipopolysaccharide biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54187	94181
Ensembl	ENSG00000095380	ENSMUSG00000028334
UniProt	Q9NR45 Q5TBR0	n/a
RefSeq (mRNA)	NM_018946	NM_053179
RefSeq (protein)	NP_061819.2	n/a
Location (UCSC)	Chr 9: 98.06 – 98.08 Mb	Chr 4: 46.49 – 46.5 Mb
PubMed search	[1]	[2]
Wikidata

Sialic acid synthase is an enzyme that in humans is encoded by the NANS gene.^[3][4]

This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively. However, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant.^[4]

References

Further reading

PDB gallery
1wvo: Solution structure of RSGI RUH-029, an antifreeze protein like domain in human N-acetylneuraminic acid phosphate synthase gene.