Mugineic-acid 3-dioxygenase
| Mugineic-acid 3-dioxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.11.25 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Mugineic-acid 3-dioxygenase (EC 1.14.11.25, IDS2) is an enzyme with systematic name mugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating).[1][2] This enzyme catalyses the following chemical reaction
- (1) mugineic acid + 2-oxoglutarate + O2 3-epihydroxymugineic acid + succinate + CO2
- (2) 2'-deoxymugineic acid + 2-oxoglutarate + O2 3-epihydroxy-2'-deoxymugineic acid + succinate + CO2
Mugineic-acid 3-dioxygenase contains iron(II). Mugineic acid is an amino acid excreted by some graminaceous (grassy) plants under conditions of iron deficiency as part of a strategy of solubilizing Fe from the root environment for uptake by the plant. Mugineic acid is closely related to its biochemical precursor, nicotinamine, and to a number of other compounds that also have been identified as phytosiderophores in graminaceous plants: 3-hydroxymugineic acid, 2'-deoxymugineic acid, avenic acid, and distichonic acid. The effectiveness of mugineic acid under iron-deficient conditions is dependent not only upon the iron chelating properties of the Fe-mugineic acid complex itself but also upon the presence of a plant membrane carrier that recognizes and absorbs the Fe-mugineic acid complex almost exclusively.[3]
References
- ↑ Nakanishi, H.; Yamaguchi, H.; Sasakuma, T.; Nishizawa, N.K.; Mori, S. (2000). "Two dioxygenase genes, Ids3 and Ids2, from Hordeum vulgare are involved in the biosynthesis of mugineic acid family phytosiderophores". Plant Mol. Biol. 44 (2): 199–207. doi:10.1023/A:1006491521586. PMID 11117263.
- ↑ Okumura, N.; Nishizawa, N.K.; Umehara, Y.; Ohata, T.; Nakanishi, H.; Yamaguchi, T.; Chino, M.; Mori. S. (1994). "A dioxygenase gene (Ids2) expressed under iron deficiency conditions in the roots of Hordeum vulgare". Plant Mol. Biol. 25 (4): 705–719. doi:10.1007/BF00029608. PMID 8061321.
- ↑ http://www.soils.wisc.edu/~barak/images/mug_frm.htm
External links
- Mugineic-acid 3-dioxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)