MCL1

MCL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KBW, 2MHS, 2NL9, 2NLA, 2PQK, 3D7V, 3IO9, 3KJ0, 3KJ1, 3KJ2, 3KZ0, 3MK8, 3PK1, 3TWU, 3WIX, 3WIY, 4BPI, 4BPJ, 4HW2, 4HW3, 4HW4, 4OQ5, 4OQ6, 4WGI, 4WMR, 4WMS, 4WMT, 4WMU, 4WMV, 4WMW, 4WMX, 4ZBF, 4ZBI, 5FDO, 5FDR, 5FC4, 5C3F
Identifiers
Aliases	MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT, myeloid cell leukemia 1, BCL2 family apoptosis regulator
External IDs	MGI: 101769 HomoloGene: 7413 GeneCards: MCL1
Gene ontology Molecular function • BH3 domain binding • protein homodimerization activity • protein binding • protein heterodimerization activity • protein channel activity Cellular component • cytoplasm • integral component of membrane • cytosol • membrane • Bcl-2 family protein complex • nucleoplasm • mitochondrial outer membrane • mitochondrial matrix • mitochondrion • nucleus Biological process • regulation of apoptotic process • cell differentiation • response to cytokine • negative regulation of intrinsic apoptotic signaling pathway • cellular homeostasis • multicellular organism development • positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway • apoptotic mitochondrial changes • intrinsic apoptotic signaling pathway in response to DNA damage • extrinsic apoptotic signaling pathway in absence of ligand • cell fate determination • regulation of response to DNA damage stimulus • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of anoikis • apoptotic process • negative regulation of apoptotic process • protein transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4170	17210
Ensembl	ENSG00000143384	ENSMUSG00000038612
UniProt	Q07820	P97287
RefSeq (mRNA)	NM_182763 NM_001197320 NM_021960	NM_008562
RefSeq (protein)	NP_001184249.1 NP_068779.1 NP_877495.1	NP_032588.1
Location (UCSC)	Chr 1: 150.57 – 150.58 Mb	Chr 3: 95.66 – 95.66 Mb
PubMed search	[1]	[2]
Wikidata

Induced myeloid leukemia cell differentiation protein Mcl-1 is a protein that in humans is encoded by the MCL1 gene.^[3][4]

Function

The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.^[5]

Clinical significance

Omacetaxine mepesuccinate (a drug approved for the treatment for chronic myelogenous leukemia (CML)) and Seliciclib ^[6] (which is under investigation as a potential multiple myeloma treatment) both act in part by inhibiting synthesis of Mcl-1.

Interactions

MCL1 has been shown to interact with:

• BAK1,^{[7][8][9][10]}
• BCL2L11,^[10][11][12]
• BID,^[9][11]
• BAD,^[11][13]
• DAD1,^[14]
• PMAIP1,^[8][11]
• PCNA,^[15]
• TCTP^[16] and
• TNKS^[17]

See also

• Bcl-2
• Bcl-xL

References

Further reading

PDB gallery
2nl9: Crystal structure of the Mcl-1:Bim BH3 complex  2nla: Crystal structure of the Mcl-1:mNoxaB BH3 complex