McN5652

McN5652
Names

IUPAC name rel-(6R,10bS)-6-[4-(Methylsulfanyl)phenyl]-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline
Other names trans-McN-5652
Identifiers
CAS Number	96795-89-0 (±)-trans^N
3D model (Jmol)	Interactive image
ChEMBL	ChEMBL361259^Y
ChemSpider	4891622^Y
PubChem	6336338
InChI InChI=1S/C19H21NS/c1-21-15-10-8-14(9-11-15)18-13-20-12-4-7-19(20)17-6-3-2-5-16(17)18/h2-3,5-6,8-11,18-19H,4,7,12-13H2,1H3/t18-,19+/m1/s1^Y Key: YVKDUIAAPBKHMJ-MOPGFXCFSA-N^Y InChI=1/C19H21NS/c1-21-15-10-8-14(9-11-15)18-13-20-12-4-7-19(20)17-6-3-2-5-16(17)18/h2-3,5-6,8-11,18-19H,4,7,12-13H2,1H3/t18-,19+/m1/s1 Key: YVKDUIAAPBKHMJ-MOPGFXCFBW
SMILES CSC1=CC=C([C@H]2CN3[C@](CCC3)([H])C4=C2C=CC=C4)C=C1
Properties
Chemical formula	C₁₉H₂₁NS
Molar mass	295.44 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is ^YN ?)
Infobox references

McN5652^[1] is a molecule that can be radiolabeled and then used as a radioligand in positron emission tomography (PET) studies. The [¹¹C]-(+)-McN5652 enantiomer binds to the serotonin transporter.^[2]

The radioligand is used for molecular neuroimaging, but also for imaging of the lungs.^[3]

References

↑ US 4595688 Certain Hexahydro-6-Arylprylpyrrolo [2,1-A]Isoquinoline
↑ M. Suehiro; U. Scheffel; H. T. Ravert; R. F. Dannals; H. N. Jr Wagner (1993). "[¹¹C](+)McN5652 as a radiotracer for imaging serotonin uptake sites with PET". Life Sciences. 53 (11): 883–882. doi:10.1016/0024-3205(93)90440-E. PMID 8366755.
↑ Akihiro Takano; Hiroshi Ito; Yasuhiko Sudo; Makoto Inoue; Tetsuya Ichimiya; Fumihiko Yasuno; Kazutoshi Suzuki; Tetsuya Suhara (August 2007). "Effects of smoking on the lung accumulation of [¹¹C]McN5652". Annals of Nuclear Medicine. 21 (6): 349–344. doi:10.1007/s12149-007-0031-1. PMID 17705015.

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