Marneral synthase

Marneral synthase (EC 5.4.99.53) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, marneral-forming).^[1] This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene

\rightleftharpoons

marneral

Marneral is a triterpenoid formed by Grob fragmentation of the A ring of 2,3-epoxy-2,3-dihydrosqualene during cyclization. This aldehyde gains its name from its structural similarity to a class triterpenes commonly found in members of the Iridaceae, originally identified by Dr. Franz-Josef Marner.^[2]

This enzyme is a member of a metabolic gene cluster along with two other cytochrome P450s.^[3]

References

↑ Xiong, Quanbo; Wilson, William K.; Matsuda, Seiichi P. T. (2006-02-13). "An Arabidopsis oxidosqualene cyclase catalyzes iridal skeleton formation by Grob fragmentation". Angewandte Chemie (International Ed. in English). 45 (8): 1285–1288. doi:10.1002/anie.200503420. ISSN 1433-7851. PMID 16425307.
↑ Xiong, Quanbo; Wilson, William K.; Matsuda, Seiichi P. T. (2006-02-13). "An Arabidopsis oxidosqualene cyclase catalyzes iridal skeleton formation by Grob fragmentation". Angewandte Chemie (International Ed. in English). 45 (8): 1285–1288. doi:10.1002/anie.200503420. ISSN 1433-7851. PMID 16425307.
↑ Field, Ben; Fiston-Lavier, Anna-Sophie; Kemen, Ariane; Geisler, Katrin; Quesneville, Hadi; Osbourn, Anne E. (2011-09-20). "Formation of plant metabolic gene clusters within dynamic chromosomal regions". Proceedings of the National Academy of Sciences. 108 (38): 16116–16121. doi:10.1073/pnas.1109273108. ISSN 0027-8424. PMC 3179108. PMID 21876149.

External links

Marneral synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

Isomerase: mutases (EC 5.4)

5.4.1 Acyl Groups	Lysolecithin acylmutase Precorrin-8X methylmutase

5.4.2 Phosphomutases	Phosphoglycerate mutase Bisphosphoglycerate mutase Phosphoglucomutase Phosphomannomutase PMM1 PMM2

5.4.99 Other groups	Methylmalonyl-CoA mutase Lanosterol synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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