MPST

MPST
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases MPST, MST, TST2, TUM1, mercaptopyruvate sulfurtransferase
External IDs MGI: 2179733 HomoloGene: 31942 GeneCards: MPST
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

4357

246221

Ensembl

ENSG00000128309

ENSMUSG00000071711

UniProt

P25325

Q99J99

RefSeq (mRNA)

NM_001013436
NM_001013440
NM_001130517
NM_021126

NM_001162492
NM_001162493
NM_138670

RefSeq (protein)

NP_001013454.1
NP_001123989.1
NP_066949.2

n/a

Location (UCSC) Chr 22: 37.02 – 37.03 Mb Chr 15: 78.41 – 78.41 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

3-mercaptopyruvate sulfurtransferase is an enzyme that in humans is encoded by the MPST gene.[3][4]

This gene encodes a protein which can function as a monomer or as a disulfide-linked homodimer and which catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cyanide degradation and in thiosulfate biosynthesis. The encoded cytoplasmic protein is a member of the rhodanese family but is not rhodanese itself, which is a mitochondrial protein. Alternatively spliced transcript variants encoding the same protein have been identified.[4]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Pallini R, Guazzi GC, Cannella C, Cacace MG (Dec 1991). "Cloning and sequence analysis of the human liver rhodanese: comparison with the bovine and chicken enzymes". Biochem Biophys Res Commun. 180 (2): 887–93. doi:10.1016/S0006-291X(05)81148-9. PMID 1953758.
  4. 1 2 "Entrez Gene: MPST mercaptopyruvate sulfurtransferase".

Further reading


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