Multiple inositol-polyphosphate phosphatase

Thus, the two substrates of this enzyme are myo-inositol hexakisphosphate and H₂O, whereas its two products are myo-inositol pentakisphosphate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 1D-myo-inositol-hexakisphosphate 5-phosphohydrolase. Other names in common use include inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase, inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase, inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase, inositol tetrakisphosphate phosphomonoesterase, inositol-1,3,4,5-tetrakisphosphate 3-phosphatase, and MIPP. This enzyme participates in inositol phosphate metabolism.

References

Cullen PJ, Irvine RF, Drobak BK, Dawson AP (1989). "Inositol 1,3,4,5-tetrakisphosphate causes release of Ca2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate". Biochem. J. 259 (3): 931–3. PMC 1138610. PMID 2786415.
Craxton A, Caffrey JJ, Burkhart W, Safrany ST, Shears SB. "Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase". Biochem. J. 328: 75–81. PMC 1218889. PMID 9359836.

Anabolism

to diacylglycerol: Acyltransferase Phosphatidate phosphatase 2C

Choline kinase CHKA CHKB Choline-phosphate cytidylyltransferase

phosphatidylinositol glycan anchor biosynthesis: PIGA PIGB PIGC PIGF PIGG PIGH PIGK PIGL PIGM PIGN PIGO PIGP PIGQ PIGS PIGT PIGU PIGV PIGW PIGX PIGY PIGZ

cardiolipin: Tafazzin

Catabolism

Phospholipase C

Diacylglycerol kinase DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ DGKZ

Phosphoric monoester hydrolases Inositol-phosphate phosphatase

Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases

Lipase

Phospholipase
- A1
- A2
- B

3.1.2: Thioesterase

3.1.3: Phosphatase

3.1.4: Phosphodiesterase

3.1.6: Sulfatase

Nuclease (includes
deoxyribonuclease and
ribonuclease)

3.1.11-16: Exonuclease

Exodeoxyribonuclease	RecBCD

Exoribonuclease	Oligonucleotidase

3.1.21-31: Endonuclease

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme UvrABC endonuclease

Endoribonuclease	RNase III RNase H 1 2A 2B 2C RNase P RNase A 1 2 3 4/5 RNase T1 RNA-induced silencing complex

either deoxy- or ribo-	Aspergillus nuclease S1 Micrococcal nuclease

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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