MED8

MED8
Identifiers
Aliases MED8, ARC32, mediator complex subunit 8
External IDs MGI: 1915269 HomoloGene: 10560 GeneCards: MED8
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

112950

80509

Ensembl

ENSG00000159479

ENSMUSG00000006392

UniProt

Q96G25

Q9D7W5

RefSeq (mRNA)

NM_201542
NM_001001653
NM_052877

NM_001290688
NM_020000
NM_173719

RefSeq (protein)

NP_001001653.1
NP_443109.2
NP_963836.2

NP_001277617.1
NP_064384.2
NP_776067.1

Location (UCSC) Chr 1: 43.38 – 43.39 Mb Chr 4: 118.41 – 118.42 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Mediator of RNA polymerase II transcription subunit 8 is an enzyme that in humans is encoded by the MED8 gene.[3][4][5]

Function

This gene encodes a protein that is one of more than 20 subunits of the mediator complex, first identified in S. cerevisiae, that is required for activation of transcription. The product of this gene also interacts with elongins B and C, and CUL2 and RBX1, to reconstitute a ubiquitin ligase. Five alternative transcripts encoding four isoforms have been described.[5]

Interactions

MED8 has been shown to interact with MED26.[6]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Brower CS, Sato S, Tomomori-Sato C, Kamura T, Pause A, Stearman R, Klausner RD, Malik S, Lane WS, Sorokina I, Roeder RG, Conaway JW, Conaway RC (Aug 2002). "Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase". Proc Natl Acad Sci U S A. 99 (16): 10353–8. doi:10.1073/pnas.162424199. PMC 124918Freely accessible. PMID 12149480.
  4. Jiang YW, Veschambre P, Erdjument-Bromage H, Tempst P, Conaway JW, Conaway RC, Kornberg RD (Aug 1998). "Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways". Proc Natl Acad Sci U S A. 95 (15): 8538–43. doi:10.1073/pnas.95.15.8538. PMC 21111Freely accessible. PMID 9671713.
  5. 1 2 "Entrez Gene: MED8 mediator of RNA polymerase II transcription, subunit 8 homolog (S. cerevisiae)".
  6. Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC (Jun 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell. 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.

Further reading


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