MED27

MED27
Identifiers
Aliases MED27, CRAP34, CRSP34, CRSP8, TRAP37, MED3, mediator complex subunit 27
External IDs MGI: 1916225 HomoloGene: 3152 GeneCards: MED27
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

9442

68975

Ensembl

ENSG00000160563

ENSMUSG00000026799

UniProt

Q6P2C8

Q9DB40

RefSeq (mRNA)

NM_001253881
NM_001253882
NM_004269

NM_001290489
NM_026896
NM_029615
NM_001290490

RefSeq (protein)

NP_001240810.1
NP_001240811.1
NP_004260.2

NP_081172.2
NP_083891.1

Location (UCSC) Chr 9: 131.86 – 132.08 Mb Chr 2: 29.35 – 29.52 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse
Med27
Identifiers
Symbol Med27
Pfam PF11571
InterPro IPR021627

Mediator of RNA polymerase II transcription subunit 27 is an enzyme that in humans is encoded by the MED27 gene.[3][4] It forms part of the Mediator complex.

The ubiquitous expression of Med27 mRNA suggests a universal requirement for Med27 in transcriptional initiation. Loss of Crsp34/Med27 decreases amacrine cell number, but increases the number of rod photoreceptor cells.[5]

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.[4]

See also

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Ryu S, Zhou S, Ladurner AG, Tjian R (Feb 1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature. 397 (6718): 446–50. doi:10.1038/17141. PMID 9989412.
  4. 1 2 "Entrez Gene: CRSP8 cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa".
  5. Dürr K, Holzschuh J, Filippi A, Ettl AK, Ryu S, Shepherd IT, Driever W (October 2006). "Differential roles of transcriptional mediator complex subunits Crsp34/Med27, Crsp150/Med14 and Trap100/Med24 during zebrafish retinal development". Genetics. 174 (2): 693–705. doi:10.1534/genetics.105.055152. PMC 1602071Freely accessible. PMID 16582438.

This article incorporates text from the public domain Pfam and InterPro IPR021627

Further reading


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