MCM10

MCM10
Identifiers
Aliases MCM10, CNA43, DNA43, PRO2249, minichromosome maintenance 10 replication initiation factor
External IDs MGI: 1917274 HomoloGene: 41275 GeneCards: MCM10
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

55388

70024

Ensembl

ENSG00000065328

ENSMUSG00000026669

UniProt

Q7L590

Q0VBD2

RefSeq (mRNA)

NM_018518
NM_182751

NM_027290
NM_001305259

RefSeq (protein)

NP_060988.3
NP_877428.1

NP_001292188.1
NP_081566.2

Location (UCSC) Chr 10: 13.16 – 13.21 Mb Chr 2: 4.99 – 5.01 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Protein MCM10 homolog is a protein that in humans is encoded by the MCM10 gene.[3][4][5]

Function

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.[5]

Interactions

MCM10 has been shown to interact with ORC2L.[3]

References

Further reading


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