MCC (gene)

MCC
Identifiers
Aliases MCC, MCC1, mutated in colorectal cancers
External IDs MGI: 96930 HomoloGene: 20539 GeneCards: MCC
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

4163

328949

Ensembl

ENSG00000171444

ENSMUSG00000071856

UniProt

P23508

n/a

RefSeq (mRNA)

NM_001085377
NM_002387

NM_001033406
NM_001085373
NM_001085374

RefSeq (protein)

NP_001078846.1
NP_002378.1

n/a

Location (UCSC) Chr 5: 113.02 – 113.49 Mb Chr 18: 44.43 – 44.81 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Colorectal mutant cancer protein is a protein that in humans is encoded by the MCC gene.[3][4]

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.[4]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Kinzler KW, Nilbert MC, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hamilton SR, Hedge P, Markham A, et al. (Apr 1991). "Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers". Science. 251 (4999): 1366–70. doi:10.1126/science.1848370. PMID 1848370.
  4. 1 2 "Entrez Gene: MCC mutated in colorectal cancers".

Further reading


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