MAP7

MAP7
Identifiers
Aliases MAP7, E-MAP-115, EMAP115, microtubule associated protein 7
External IDs MGI: 1328328 HomoloGene: 20851 GeneCards: MAP7
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

9053

17761

Ensembl

ENSG00000135525

ENSMUSG00000019996

UniProt

Q14244

O88735

RefSeq (mRNA)

NM_001198635
NM_001198636
NM_008635

RefSeq (protein)

NP_001185564.1
NP_032661.2

Location (UCSC) Chr 6: 136.34 – 136.55 Mb Chr 10: 20.15 – 20.28 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Ensconsin is a protein that in humans is encoded by the MAP7 gene.[3][4]

Function

The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis.[4]

Interactions

MAP7 has been shown to interact with TRPV4.[5]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Masson D, Kreis TE (Nov 1993). "Identification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominantly expressed in epithelial cells". J Cell Biol. 123 (2): 357–71. doi:10.1083/jcb.123.2.357. PMC 2119845Freely accessible. PMID 8408219.
  4. 1 2 "Entrez Gene: MAP7 microtubule-associated protein 7".
  5. ↑ Suzuki M, Hirao A, Mizuno A (December 2003). "Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4)". J. Biol. Chem. 278 (51): 51448–53. doi:10.1074/jbc.M308212200. PMID 14517216.

Further reading

  • Masson D, Kreis TE (1996). "Binding of E-MAP-115 to microtubules is regulated by cell cycle-dependent phosphorylation.". J. Cell Biol. 131 (4): 1015–24. doi:10.1083/jcb.131.4.1015. PMC 2200015Freely accessible. PMID 7490279. 
  • Fabre-Jonca N, Viard I, French LE, Masson D (1999). "Upregulation and redistribution of E-MAP-115 (epithelial microtubule-associated protein of 115 kDa) in terminally differentiating keratinocytes is coincident with the formation of intercellular contacts.". J. Invest. Dermatol. 112 (2): 216–25. doi:10.1046/j.1523-1747.1999.00500.x. PMID 9989799. 
  • Bulinski JC, Odde DJ, Howell BJ, Salmon TD, Waterman-Storer CM (2002). "Rapid dynamics of the microtubule binding of ensconsin in vivo.". J. Cell. Sci. 114 (Pt 21): 3885–97. PMID 11719555. 
  • Penttilä TL, Parvinen M, Paranko J (2004). "Microtubule-associated epithelial protein E-MAP-115 is localized in the spermatid manchette.". Int. J. Androl. 26 (3): 166–74. doi:10.1046/j.1365-2605.2003.00406.x. PMID 12755995. 
  • Vanier MT, Deck P, Stutzmann J, Gendry P, Arnold C, Dirrig-Grosch S, Kedinger M, Launay JF (2004). "Expression and distribution of distinct variants of E-MAP-115 during proliferation and differentiation of human intestinal epithelial cells.". Cell Motil. Cytoskeleton. 55 (4): 221–31. doi:10.1002/cm.10124. PMID 12845596. 
  • Suzuki M, Hirao A, Mizuno A (2004). "Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4).". J. Biol. Chem. 278 (51): 51448–53. doi:10.1074/jbc.M308212200. PMID 14517216. 
  • Sood R, Bader PI, Speer MC, Edwards YH, Eddings EM, Blair RT, Hu P, Faruque MU, Robbins CM, Zhang H, Leuders J, Morrison K, Thompson D, Schwartzberg PL, Meltzer PS, Trent JM (2004). "Cloning and characterization of an inversion breakpoint at 6q23.3 suggests a role for Map7 in sacral dysgenesis.". Cytogenet. Genome Res. 106 (1): 61–7. doi:10.1159/000078563. PMID 15218243. 
  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365Freely accessible. PMID 16565220. 
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. 
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 


This article is issued from Wikipedia - version of the 5/20/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.