Loewe additivity

In Pharmacology, Loewe Additivity is one of several common reference models used for measuring the effects of drug combinations.

Loewe additivity is based on the idea that an agent should not have synergistic interactions with itself or like agents.

To better understand the model of Loewe Additivity, an additive drug could be shown with a basic formula:

If drug x and drug y are similar drugs, 
a dose of x and y (at equal concentration) 
will replicate the effect of double the dose (2x), of either drug.

IF x=y , THEN x+y → 2x.

The reverse of this scenario is known as hyper-antagonism.

References

William R Greco, Gregory Bravo, and John Parsons "The Search for Synergy: A Critical Review from a Response Surface Perspective", Pharmacological Reviews 47(2) 331-385 (1995)
Loewe and Muischnek. "Effect of combinations: mathematical basis of the problem" Arch. Exp. Pathol. Pharmakol. 114: 313-326, 1926
Pamela J. Yeh, Matthew J. Hegreness, Aviva Presser Aiden & Roy Kishony "Nature Reviews Microbiology" 7, 460-466 (June 2009)

This article is issued from Wikipedia - version of the 9/10/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.