List of SJS-inducing substances

This is a list of drugs and substances that are known to be, or are suspected to be implicated in causing Stevens–Johnson syndrome.

Name Other names
Acetaminophen[1][2] Paracetamol, Tylenol
Allopurinol[3]
Amoxicillin[4]
Ampicillin[4]
Azithromycin [5] Zithromax
Barbiturates[6]
Carbamazepine[7]
Ciprofloxacin/levofloxacin/Gemifloxacin
Clozapine [8] Clozaril
Diclofenac[9]
Ethosuximide
Ibuprofen[10]
Isotretinoin[11] Accutane
Lamotrigine[12] Lamictal
Modafinil[13] Provigil
Nevirapine
Oseltamivir
Penicillins[7]
Phenytoin[7]
Sitagliptin
Sulfonamides[4]
Tetracycline[4]
  1. ↑ Khawaja A, Shahab A, Hussain SA (May 2012). "Acetaminophen-induced Steven Johnson syndrome-toxic epidermal necrolysis overlap". J Pak Med Assoc. 62: 524–7. PMID 22755330.
  2. ↑ "Stevens-Jonhson syndrome after acetaminophen ingestion, confirmed by challenge test in an eleven-year-old patient". the Journal: Allergologia et Immunopathologia.
  3. ↑ Harr T, French LE (2012). "Adverse Cutaneous Drug Eruptions". Chem Immunol Allergy. Karger, Basel. 97 (1): 149–166. doi:10.1159/000335627. PMID 22613860. |chapter= ignored (help)
  4. 1 2 3 4 "Stevens Johnson Syndrome". WebMD.
  5. ↑ See, e.g.: Schultz, Laura (December 28, 2015). "Potential Zithromax Side Effects Include Stevens Johnson Syndrome". Top Class Actions, LLC. Archived from the original on December 28, 2015. Retrieved December 28, 2015. Several Zithromax lawsuits have been filed against Pfizer alleging that the drug maker failed to warn the medical community and the public about serious risks associated with taking the antibiotic.
  6. ↑ Mamishi, Setareh; Fattahi, Fatemeh; Pourpak, Zahra; Aghaee, Farzaneh Mirza; Moinfar, Zeinab; Mohammadi, Mahmoud; Ashrafi, Mahmoud; Moin, Mostafa (2009-11-01). "Severe cutaneous reactions caused by barbiturates in seven Iranian children". International Journal of Dermatology. 48 (11): 1254–1261. doi:10.1111/j.1365-4632.2007.03561.x. ISSN 1365-4632. PMID 20064188.
  7. 1 2 3 Rehmus, Wingfield E (November 2013). "Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)". Merck Manual. Merck Sharp & Dohme Corp.
  8. ↑ Wu, Ming-Kung; Chung, Weilun; Wu, Ching-Kuan; Tseng, Ping-Tao (2015-01-01). "The severe complication of Stevens-Johnson syndrome induced by long-term clozapine treatment in a male schizophrenia patient: a case report". Neuropsychiatric Disease and Treatment. 11: 1039–1041. doi:10.2147/NDT.S79327. ISSN 1176-6328. PMC 4399514Freely accessible. PMID 25914536.
  9. ↑ Roujeau, J.-C., Kelly, J. P., Naldi, L., Rzany, B., Stern, R. S., Anderson, T., Auquier, A., Bastuji-Garin, S., Correia, O., Locati, F., Mockenhaupt, M., Paoletti, C., Shapiro, S., Shear, N., Schopf, E., Kaufman, D. W. (1995). "Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis.". N Engl J Med. 333 (1): 1600–1607. doi:10.1056/NEJM199512143332404. PMID 7477195.
  10. ↑ Raksha MP, Marfatia YS (2008). "Clinical study of cutaneous drug eruptions in 200 patients". Indian J Dermatol Venereol Leprol. 74 (1): 80. doi:10.4103/0378-6323.38431. PMID 18193504.
  11. ↑ Medsafe Data Sheet March 8, 2005. Accessed April 26, 2007.
  12. ↑ "LAMICTAL PRESCRIBING INFORMATION" (PDF). GlaxoSmithKline.
  13. ↑ "PROVIGIL PRESCRIBING INFORMATION" (PDF). Cephalon, Inc.
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