LZTS1

LZTS1
Identifiers
Aliases LZTS1, F37, FEZ1, leucine zipper, putative tumor suppressor 1
External IDs MGI: 2684762 HomoloGene: 10873 GeneCards: LZTS1
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

11178

211134

Ensembl

ENSG00000061337

ENSMUSG00000036306

UniProt

Q9Y250

P60853

RefSeq (mRNA)

NM_021020

NM_199364

RefSeq (protein)

NP_066300.1

NP_955396.2

Location (UCSC) Chr 8: 20.25 – 20.3 Mb Chr 8: 69.13 – 69.18 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Leucine zipper putative tumor suppressor 1 is a protein that, in humans, is encoded by the LZTS1 gene.[3][4][5]

In melanocytic cells LZTS1 gene expression may be regulated by MITF.[6]

Interactions

LZTS1 has been shown to interact with EEF1G.[7]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Ishii H, Baffa R, Numata SI, Murakumo Y, Rattan S, Inoue H, Mori M, Fidanza V, Alder H, Croce CM (May 1999). "The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors". Proc Natl Acad Sci U S A. 96 (7): 3928–33. doi:10.1073/pnas.96.7.3928. PMC 22397Freely accessible. PMID 10097140.
  4. ↑ Vecchione A, Baldassarre G, Ishii H, Nicoloso MS, Belletti B, Petrocca F, Zanesi N, Fong LY, Battista S, Guarnieri D, Baffa R, Alder H, Farber JL, Donovan PJ, Croce CM (Mar 2007). "Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development". Cancer Cell. 11 (3): 275–89. doi:10.1016/j.ccr.2007.01.014. PMC 1987708Freely accessible. PMID 17349584.
  5. ↑ "Entrez Gene: LZTS1 leucine zipper, putative tumor suppressor 1".
  6. ↑ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
  7. ↑ Ishii H, Vecchione A, Murakumo Y, Baldassarre G, Numata S, Trapasso F, Alder H, Baffa R, Croce CM (Aug 2001). "FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10374–9. doi:10.1073/pnas.181222898. PMC 56968Freely accessible. PMID 11504921.

Further reading

  • Ono K, Uzawa K, Nakatsuru M, Shiiba M, Mochida Y, Tada A, Bukawa H, Miyakawa A, Yokoe H, Tanzawa H (2004). "Down-regulation of FEZ1/LZTS1 gene with frequent loss of heterozygosity in oral squamous cell carcinomas.". Int. J. Oncol. 23 (2): 297–302. doi:10.3892/ijo.23.2.297. PMID 12851677. 
  • Hawkins GA, Mychaleckyj JC, Zheng SL, Faith DA, Kelly B, Isaacs SD, Wiley KE, Chang BL, Ewing CM, Bujnovszky P, Bleecker ER, Walsh PC, Meyers DA, Isaacs WB, Xu J (2002). "Germline sequence variants of the LZTS1 gene are associated with prostate cancer risk.". Cancer Genet. Cytogenet. 137 (1): 1–7. doi:10.1016/S0165-4608(02)00549-6. PMID 12377406. 
  • Ishii H, Vecchione A, Murakumo Y, Baldassarre G, Numata S, Trapasso F, Alder H, Baffa R, Croce CM (2001). "FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis.". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10374–9. doi:10.1073/pnas.181222898. PMC 56968Freely accessible. PMID 11504921. 
  • Cabeza-Arvelaiz Y, Sepulveda JL, Lebovitz RM, Thompson TC, Chinault AC (2001). "Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22.". Oncogene. 20 (31): 4169–79. doi:10.1038/sj.onc.1204539. PMID 11464283. 


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