KCNB1

Identifiers

Aliases

KCNB1, DRK1, KV2.1, h-DRK1, EIEE26, potassium voltage-gated channel subfamily B member 1

External IDs

MGI: 96666 HomoloGene: 37988 GeneCards: KCNB1

Genetically Related Diseases

obesity^[1]

Targeted by Drug

linoleic acid^[2]

Gene ontology
Molecular function	• potassium channel activity • ion channel binding • ubiquitin-like protein binding • voltage-gated ion channel activity • ion channel activity • protein binding • protein heterodimerization activity • voltage-gated potassium channel activity • delayed rectifier potassium channel activity
Cellular component	• integral component of membrane • perikaryon • postsynaptic membrane • cell projection • lateral plasma membrane • membrane • voltage-gated potassium channel complex • plasma membrane • synapse • axon • cell junction • dendrite • neuron projection • sarcolemma • intracellular • neuronal cell body membrane
Biological process	• exocytosis • positive regulation of norepinephrine secretion • glutamate receptor signaling pathway • regulation of insulin secretion • regulation of ion transmembrane transport • positive regulation of catecholamine secretion • ion transport • vesicle docking involved in exocytosis • protein targeting to plasma membrane • positive regulation of calcium ion-dependent exocytosis • potassium ion transport • regulation of motor neuron apoptotic process • transmembrane transport • cellular response to nutrient levels • potassium ion transmembrane transport • transport • action potential • protein homooligomerization • positive regulation of protein targeting to membrane • positive regulation of long term synaptic depression • regulation of action potential • negative regulation of insulin secretion • glucose homeostasis • cellular response to glucose stimulus
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


3745


16500

Ensembl


ENSG00000158445


ENSMUSG00000050556

UniProt


Q14721


Q03717

RefSeq (mRNA)


NM_004975


NM_008420

RefSeq (protein)


NP_004966.1


NP_032446.2

Location (UCSC)

Chr 20: 49.36 – 49.48 Mb

Chr 2: 167.1 – 167.19 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium voltage-gated channel, Shab-related subfamily, member 1, also known as KCNB1 or K_v2.1, is a protein that, in humans, is encoded by the KCNB1 gene.^[5]^[6]^[7]

Species and tissue distribution

K_v2.1 channels are widely expressed in various tissues in mammals, including humans. They are found in cardiomyocytes, skeletal muscles, vascular smooth muscles, placental vasculature, retina, and pancreatic β-cells.

Function

Voltage-gated potassium (K_v) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members.^[5]

In mouse cardiomyocytes, K_v2.1 channel is the molecular substrate of major repolarization current I_K-slow2. Transgenic mice, expressing a dominant-negative isoform of K_v2.1, exhibit markedly prolonged action potentials and demonstrate arrhythmia. In mammalian CNS neurons, K_v2.1 is a predominant delayed rectifier K⁺ current that regulates neuronal excitability, action potential duration, and tonic spiking.^[8] In Drosophila photoreceptor cells, the K_v2 channel is the key component of light-induced membrane voltage response. Genetic abolition of this current dramatically decreases photoreceptor information capacity.

Interactions

KCNB1 has been shown to interact with:

KCNH1,^[9] and
PTPRE.^[10]

References

↑ "Diseases that are genetically associated with KCNB1 view/edit references on wikidata".
↑ "Drugs that physically interact with Potassium voltage-gated channel subfamily B member 1 view/edit references on wikidata".
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 "Entrez Gene: KCNB1 potassium voltage-gated channel, Shab-related subfamily, member 1".
↑ Melis R, Stauffer D, Zhao X, Zhu XL, Albrecht B, Pongs O, Brothman A, Leppert M (January 1995). "Physical and genetic localization of a Shab subfamily potassium channel (KCNB1) gene to chromosomal region 20q13.2". Genomics. 25 (1): 285–7. doi:10.1016/0888-7543(95)80138-C. PMID 7774931.
↑ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.
↑ Murakoshi, H; Trimmer JS (March 1999). "Identification of the Kv2.1 K+ channel as a major component of the delayed rectifier K+ current in rat hippocampal neurons.". J Neurosci. 19 (5): 1728–35. PMID 10024359.
↑ Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ (June 2002). "Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 7986–91. doi:10.1073/pnas.122617999. PMC 123007. PMID 12060745.
↑ Peretz A, Gil-Henn H, Sobko A, Shinder V, Attali B, Elson A (August 2000). "Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon". EMBO J. 19 (15): 4036–45. doi:10.1093/emboj/19.15.4036. PMC 306594. PMID 10921884.

External links

Kv2.1 Potassium Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
KCNB1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3

Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ

Proton-gated	Amiloride-sensitive cation channel 1 2 3 4

Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1

Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1

Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18

Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker gene

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B

H⁺: Proton channel	HVCN1

M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4

M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6

H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family

Cytoplasm: Gap junction	Connexin: A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4) Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

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