Kofler bench

Kofler bench with samples for calibration

A Kofler bench or Kofler hot-stage microscope is a metal strip with a temperature gradient (range room temperature to 300°C). Any substance can be placed on a section of the strip revealing its thermal behaviour at the temperature at that point.[1]

This melting-point apparatus for use with a microscope was developed by the Austrian pharmacognosist Ludwig Kofler (30 November 1891 Dornbirn - 23 August 1951 Innsbruck) and his wife Adelheid Kofler. In 1936, the Koflers and Mayrhofer published their "Mikroskopische Methoden in der Mikrochemie" [Kofler, L., A. Kofler and Mayrhofer, A. (1936)], Kofler and Kofler published their "Thermomikromethoden" [Kofler L., and A. Kofler (1954)] in 1954.[2][3]

Kofler, his wife Adelheid, and their colleague, Maria Kuhnert-Brandstätter, investigated numerous organic molecules, and published some 250 papers describing their work.[4]

Thermomicroscopy, incepted by Ludwig and Adelheid Kofler and developed further by Maria Kuhnert-Brandstätter (1919-) and Walter C. McCrone is a technique for studying the phases of solid drug substances.

See also

References

  1. ↑ http://www.reichertms.com/Manuals/Galen%20III%20Thermo%20Galen%20brochure.pdf
  2. ↑ http://www.modernmicroscopy.com/main.asp?article=69&page=12
  3. ↑ History of Pharmacy
  4. ↑ http://pubs.acs.org/action/doSearch?action=search&searchText=Kofler&qsSearchArea=searchText&type=within&publication=40025988

Further reading

External links

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