José Acosta
José Acosta may refer to:
- José Acosta (baseball) (1891–1977), Cuban baseball player
- José Gerónimo Lluberas Acosta (1956–2003), Puerto Rican physician
- José Julián Acosta (1825–1891), journalist and advocate of the abolition of slavery in Puerto Rico
- José de Acosta (1539-1600), Jesuit naturalist and missionary in Latin America
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