Jennifer Stow

Jennifer Stow
Nationality Australian
Fields Cell Biology
Institutions The University of Queensland
Harvard University
Yale University
Alma mater Monash University, Melbourne
Known for Protein trafficking and inflammation
Notable awards Fogarty International Fellowship, Yale University (1982–1985)
Wellcome Trust Senior Research Fellowship in Medical Sciences (1994–1999)
NHMRC Principal Research Fellow
State Winner, Smart Women/Smart State Award, Queensland (2007)

Jennifer Stow is deputy director (research), NHMRC Principal Research Fellow and head of the Protein Trafficking and Inflammation laboratory at the Institute for Molecular Bioscience (IMB), The University of Queensland, Australia. Jenny was awarded her PhD at Monash University in Melbourne in 1982. As a Fogarty International Fellow, she completed postdoctoral training at Yale University School of Medicine (US) in the Department of Cell Biology. She was then appointed to her first faculty position as an assistant professor at Harvard University in the Renal Unit, Departments of Medicine and Pathology at the Massachusetts General Hospital in Boston. At the end of 1994 she returned to Australia as a Wellcome Trust Senior International Medical Research fellow at The University of Queensland where her work has continued. Stow sits on national and international peer review and scientific committees and advisory boards. She has served as head of IMB's Division of Molecular Cell Biology, and in 2008 she was appointed as deputy director (research).

Biography

Jenny Stow completed her tertiary education at Monash University Melbourne. Her undergraduate science degree was followed by an honours year (Hons 1st class) in the Department of Immunology and Pathology and a PhD (1979–1982) in the Department of Anatomy and Prince Henry's Hospital, under the supervision of Professors Eric Glasgow and Robert Atkins. Stow's PhD project involved characterizing cell populations in glomerulonephritis, including the use of electron microscopy. She was then awarded a Fogarty International Fellowship for postdoctoral training in the Department of Cell Biology at Yale University School of Medicine, US, where she worked with one of the luminaries of cell biology and nephrology, Dr Marilyn Farquhar. Stow, Farquhar and colleagues published seminal studies on glomerular basement membranes and proteoglycans. Upon leaving Yale, Stow took up her first faculty position as an assistant professor in the Renal Unit at Massachusetts General Hospital at Harvard University. Stow and colleagues published important findings on secretion in polarized epithelial cells and published the first evidence showing trimeric G proteins functioning in membrane trafficking. At the end of 1994 Jenny returned to Australia as a Wellcome Trust Senior Medical Research Fellow to set up a cell biology laboratory[1] at the University of Queensland in Brisbane. The Centre she joined later became of Australia's largest research institutes, UQ's Institute for Molecular Bioscience where she has served as a group leader, professor and principal research fellow of the NHMRC. Appointed head of IMB's Division of Molecular Cell Biology and then subsequently as deputy director (research) at IMB, Stow has performed roles in science, teaching and training and research policy. Her focus has been in cell biology, where her interest in protein trafficking and secretion is pursued using techniques such as microscopy and fluorescence imaging. Her current work in inflammation and cancer focuses on trafficking in epithelial cells and on cytokine secretion in macrophages. She is known for discovering new pathways for secretion and recycling in cells and for defining new functions for the cell machinery, including large and small G proteins, myosins and SNAREs.

Career history

Career highlights

References

  1. ↑ Jennifer Stow Research Lab Homepage UQ, IMB
  2. ↑ Caplan MJ, Stow JL, Newman AP, et al. (1987). "Dependence on pH of polarized sorting of secreted proteins". Nature. 329 (6140): 632–5. doi:10.1038/329632a0. PMID 2821405.
  3. ↑ Ercolani L, Stow JL, Boyle JF, et al. (June 1990). "Membrane localization of the pertussis toxin-sensitive G-protein subunits alpha i-2 and alpha i-3 and expression of a metallothionein-alpha i-2 fusion gene in LLC-PK1 cells". Proceedings of the National Academy of Sciences of the United States of America. 87 (12): 4635–9. doi:10.1073/pnas.87.12.4635. PMC 54171Freely accessible. PMID 1693774.
  4. ↑ Le TL, Yap AS, Stow JL (July 1999). "Recycling of E-cadherin: a potential mechanism for regulating cadherin dynamics". The Journal of Cell Biology. 146 (1): 219–32. doi:10.1083/jcb.146.999.219. PMC 2199726Freely accessible. PMID 10402472.
  5. ↑ Murray RZ, Kay JG, Sangermani DG, Stow JL (December 2005). "A role for the phagosome in cytokine secretion". Science. 310 (5753): 1492–5. doi:10.1126/science.1120225. PMID 16282525.
  6. ↑ Low PC, Misaki R, Schroder K, et al. (September 2010). "Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion". The Journal of Cell Biology. 190 (6): 1053–65. doi:10.1083/jcb.201001028. PMC 3101599Freely accessible. PMID 20837769.
  7. ↑ Luo L, Wall AA, Yeo JC, et al. (2014). "Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling". Nature Communications. 5: 4407. doi:10.1038/ncomms5407. PMID 25022365.
  8. ↑ Low PC, Manzanero S, Mohannak N, et al. (2014). "PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model". Nature Communications. 5: 3450. doi:10.1038/ncomms4450. PMID 24625684.

External links

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