Interstate 395

Interstate 395 may refer to:

• Interstate 395 (District of Columbia–Virginia), a spur from I-95 to Washington, D.C.
• Interstate 395 (Connecticut–Massachusetts), a spur from I-95 to Auburn, Massachusetts
• Interstate 395 (Florida), a spur in Miami, Florida
• Interstate 395 (Maine), a spur in Bangor, Maine
• Interstate 395 (Maryland), a spur in Baltimore, Maryland
• Interstate 676, a loop through Philadelphia, Pennsylvania, formerly designated as Interstate 395