IL17RD

IL17RD
Identifiers
Aliases IL17RD, HH18, IL-17RD, IL17RLM, SEF, interleukin 17 receptor D
External IDs MGI: 2159727 HomoloGene: 9717 GeneCards: IL17RD
Orthologs
Species Human Mouse
Entrez

54756

171463

Ensembl

ENSG00000144730

ENSMUSG00000040717

UniProt

Q8NFM7

Q8JZL1

RefSeq (mRNA)

NM_017563
NM_001318864

NM_027265
NM_134437

RefSeq (protein)

NP_060033.3
NP_001305793.1

NP_602319.1

Location (UCSC) Chr 3: 57.09 – 57.17 Mb Chr 14: 27.04 – 27.11 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin 17 receptor D is a protein that in humans is encoded by the IL17RD gene. [3]

Function

This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms.

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ "Entrez Gene: Interleukin 17 receptor D". Retrieved 2016-04-17.

Further reading

  • Kovalenko D, Yang X, Nadeau RJ, Harkins LK, Friesel R (2003). "Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation". J. Biol. Chem. 278 (16): 14087–91. doi:10.1074/jbc.C200606200. PMID 12604616. 


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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