Ibogamine
Ibogamine
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Clinical data |
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ATC code |
none |
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Identifiers |
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- [6R-(6α,6aβ,7β,9α)]-7-ethyl-6,6a,7,8,9,10,12,13-octahydro-6,9-methano-5H-pyrido[1',2':1,2]azepino[4,5-b]indole
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CAS Number |
481-87-8 N |
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PubChem (CID) |
100217 |
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ChemSpider |
90568 Y |
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ChEBI |
CHEBI:5853 Y |
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Chemical and physical data |
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Formula |
C19H24N2 |
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Molar mass |
280.41 g/mol |
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InChI=1S/C19H24N2/c1-2-13-9-12-10-16-18-15(7-8-21(11-12)19(13)16)14-5-3-4-6-17(14)20-18/h3-6,12-13,16,19-20H,2,7-11H2,1H3/t12-,13+,16+,19+/m1/s1 YKey:LRLCVRYKAFDXKU-YGOSVGOTSA-N Y
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NY (what is this?) (verify) |
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Ibogamine is an alkaloid found in Tabernanthe iboga.[1][2]
Basic research related to how addiction affects the brain has used this chemical.[3]
Ibogamine persistently reduced the self-administration of cocaine and morphine in rats.[4]
See also
References
- ↑ Bartlett, M. F.; Dickel, D. F.; Taylor, W. I. (1958). "The Alkaloids of Tabernanthe iboga. Part IV.1 The Structures of Ibogamine, Ibogaine, Tabernanthine and Voacangine - Journal of the American Chemical Society (ACS Publications)". Journal of the American Chemical Society. 80 (1): 126–136. doi:10.1021/ja01534a036.
- ↑ Kuehne, Martin E.; Reider, Paul J. (1985). "A synthesis of ibogamine - The Journal of Organic Chemistry (ACS Publications)". The Journal of Organic Chemistry. 50 (9): 1464–1467. doi:10.1021/jo00209a020.
- ↑ Levi MS, Borne RF (October 2002). "A review of chemical agents in the pharmacotherapy of addiction". Curr. Med. Chem. 9 (20): 1807–18. doi:10.2174/0929867023368980. PMID 12369879.
- ↑ Glick SD, Kuehne ME, Raucci J, Wilson TE, Larson D, Keller RW Jr, Carlson JN (September 1994). "Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum.". Brain Res. 657 (1-2): 14–22. doi:10.1016/0006-8993(94)90948-2. PMID 7820611.
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MOR |
- PAMs: BMS-986121
- BMS-986122
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DOR | |
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KOR |
- Agonists: 6'-GNTI
- 8-CAC
- 18-MC
- 14-Methoxymetopon
- β-Chlornaltrexamine
- β-Funaltrexamine
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- ICI-199,441
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- RB-64
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- Samidorphan
- SKF-10047
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- TH-030418
- Thienorphine
- Tifluadom
- Tricyclic antidepressants (e.g., amitriptyline, desipramine, imipramine, nortriptyline)
- U-50,488
- U-54,494A
- U-69,593
- Xorphanol
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NOP | |
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Unsorted | |
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Others |
- Others: Kyotorphin (met-enkephalin releaser/degradation stabilizer)
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See also: Peptide receptor modulators |