INF2

INF2
Identifiers
Aliases INF2, C14orf151, C14orf173, CMTDIE, FSGS5, pp9484, inverted formin, FH2 and WH2 domain containing
External IDs MGI: 1917685 HomoloGene: 82406 GeneCards: INF2
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

64423

70435

Ensembl

ENSG00000203485

ENSMUSG00000037679

UniProt

Q27J81

Q0GNC1

RefSeq (mRNA)

NM_001031714
NM_022489
NM_032714

NM_198411

RefSeq (protein)

NP_001026884.3
NP_071934.3
NP_116103.1

NP_940803.2

Location (UCSC) Chr 14: 104.69 – 104.72 Mb Chr 12: 112.59 – 112.62 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Inverted formin-2 is a protein that in humans is encoded by the INF2 gene.[3][4] It belongs to the protein family called the formins. It has two splice isoforms, CAAX which localizes to the endoplasmic reticulum and non-CAAX which localizes to focal adhesions and the cytoplasm with enrichment at the Golgi.[5][6][7] INF2 plays a role in mitochondrial fission and dorsal stress fiber formation.[7][8] INF2 accelerates actin nucleation and elongation by interacting with barbed ends (fast-growing ends) of actin filaments, but also accelerates depolymerization of actin through encircling and severing filaments.[9]

Clinical significance

It can be associated with Focal segmental glomerulosclerosis[10] and Charcot-Marie Tooth Disease.[11]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Chhabra ES, Higgs HN (Sep 2006). "INF2 Is a WASP homology 2 motif-containing formin that severs actin filaments and accelerates both polymerization and depolymerization". J Biol Chem. 281 (36): 26754–67. doi:10.1074/jbc.M604666200. PMID 16818491.
  4. "Entrez Gene: C14orf173 chromosome 14 open reading frame 173".
  5. Ramabhadran, Vinay; Korobova, Farida; Rahme, Gilbert J.; Higgs, Henry N. (2011-12-01). "Splice variant-specific cellular function of the formin INF2 in maintenance of Golgi architecture". Molecular Biology of the Cell. 22 (24): 4822–4833. doi:10.1091/mbc.E11-05-0457. ISSN 1939-4586. PMC 3237625Freely accessible. PMID 21998196.
  6. Chhabra, Ekta Seth; Ramabhadran, Vinay; Gerber, Scott A.; Higgs, Henry N. (2009-05-01). "INF2 is an endoplasmic reticulum-associated formin protein". Journal of Cell Science. 122 (Pt 9): 1430–1440. doi:10.1242/jcs.040691. ISSN 0021-9533. PMC 2721004Freely accessible. PMID 19366733.
  7. 1 2 Skau, Colleen T.; Plotnikov, Sergey V.; Doyle, Andrew D.; Waterman, Clare M. (2015-05-12). "Inverted formin 2 in focal adhesions promotes dorsal stress fiber and fibrillar adhesion formation to drive extracellular matrix assembly". Proceedings of the National Academy of Sciences of the United States of America. 112 (19): E2447–2456. doi:10.1073/pnas.1505035112. ISSN 1091-6490. PMC 4434736Freely accessible. PMID 25918420.
  8. Korobova, Farida; Ramabhadran, Vinay; Higgs, Henry N. (2013-01-25). "An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2". Science (New York, N.Y.). 339 (6118): 464–467. doi:10.1126/science.1228360. ISSN 1095-9203. PMC 3843506Freely accessible. PMID 23349293.
  9. Gurel, Pinar S.; Ge, Peng; Grintsevich, Elena E.; Shu, Rui; Blanchoin, Laurent; Zhou, Z. Hong; Reisler, Emil; Higgs, Henry N. (2014-01-20). "INF2-mediated severing through actin filament encirclement and disruption". Current biology: CB. 24 (2): 156–164. doi:10.1016/j.cub.2013.12.018. ISSN 1879-0445. PMC 3992431Freely accessible. PMID 24412206.
  10. Brown EJ, Schlöndorff JS, Becker DJ, Tsukaguchi H, Uscinski AL, Higgs HN, Henderson JM, Pollak MR (Jan 2010). "Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis". Nature Genetics. 42 (1): 72–6. doi:10.1038/ng.505. PMC 2980844Freely accessible. PMID 20023659.
  11. Boyer, Olivia; Nevo, Fabien; Plaisier, Emmanuelle; Funalot, Benoit; Gribouval, Olivier; Benoit, Geneviève; Huynh Cong, Evelyne; Arrondel, Christelle; Tête, Marie-Josèphe (2011-12-22). "INF2 mutations in Charcot-Marie-Tooth disease with glomerulopathy". The New England Journal of Medicine. 365 (25): 2377–2388. doi:10.1056/NEJMoa1109122. ISSN 1533-4406. PMID 22187985.

Further reading


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