IGHG3

IGHG3

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
4ZNC

Identifiers

IGHG3, IgG3, immunoglobulin heavy constant gamma 3 (G3m marker)

External IDs

GeneCards: IGHG3

Gene ontology
Molecular function	• immunoglobulin receptor binding • antigen binding • serine-type endopeptidase activity
Cellular component	• extracellular space • extracellular region • blood microparticle • extracellular exosome • external side of plasma membrane • immunoglobulin complex, circulating
Biological process	• B cell receptor signaling pathway • phagocytosis, recognition • positive regulation of B cell activation • complement activation • retina homeostasis • phagocytosis, engulfment • defense response to bacterium • Fc-gamma receptor signaling pathway involved in phagocytosis • complement activation, classical pathway • innate immune response • proteolysis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


3502


n/a


n/a


n/a


P01860


n/a

RefSeq (mRNA)


n/a


n/a

RefSeq (protein)


n/a


n/a

Location (UCSC)

n/a

n/a

PubMed search

^[1]

n/a

View/Edit Human

Ig gamma-3 chain C region is a protein that in humans is encoded by the IGHG3 gene.^[2]^[3]

References

↑ "Human PubMed Reference:".
↑ Alexander A, Steinmetz M, Barritault D, Frangione B, Franklin EC, Hood L, Buxbaum JN (Sep 1982). "gamma Heavy chain disease in man: cDNA sequence supports partial gene deletion model". Proc Natl Acad Sci U S A. 79 (10): 3260–4. doi:10.1073/pnas.79.10.3260. PMC 346395. PMID 6808505.
↑ "Entrez Gene: IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker)".

Further reading

Michaelsen TE, Frangione B, Franklin EC (1977). "Primary structure of the "hinge" region of human IgG3. Probable quadruplication of a 15-amino acid residue basic unit.". J. Biol. Chem. 252 (3): 883–9. PMID 402363.
Wolfenstein-Todel C, Frangione B, Prelli F, Franklin EC (1976). "The amino acid sequence of "heavy chain disease" protein ZUC. Structure of the Fc fragment of immunoglobulin G3.". Biochem. Biophys. Res. Commun. 71 (4): 907–14. doi:10.1016/0006-291X(76)90741-5. PMID 823945.
Huck S, Fort P, Crawford DH, et al. (1986). "Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma genes.". Nucleic Acids Res. 14 (4): 1779–89. doi:10.1093/nar/14.4.1779. PMC 339572. PMID 3081877.
Frangione B, Rosenwasser E, Prelli F, Franklin EC (1980). "Primary structure of human gamma 3 immunoglobulin deletion mutant: gamma 3 heavy-chain disease protein Wis.". Biochemistry. 19 (18): 4304–8. doi:10.1021/bi00559a024. PMID 6774747.
Lewis AP, Lemon SM, Barber KA, et al. (1993). "Rescue, expression, and analysis of a neutralizing human anti-hepatitis A virus monoclonal antibody.". J. Immunol. 151 (5): 2829–38. PMID 8395549.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.

This article is issued from Wikipedia - version of the 10/17/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.