Heparan sulfate 6-O-sulfotransferase

Heparan sulfate 6-sulfotransferase

Identifiers

Symbol

HS6ST

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Heparan sulfate 6-sulfotransferases catalyses the transfer of sulfate from adenosine 3'-phosphate, 5'-phosphosulfate to the 6th position of the N-sulfoglucosamine residue in heparan sulfate.^[1]

Human proteins containing this domain

HS6ST1
HS6ST2
HS6ST3

References

↑ Matsuda Y, Kuroiwa A, Tanaka M, Habuchi H, Miyake G, Nogami K, Kusche-gullberg M, Habuchi O, Kimata K (2003). "Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties". Biochem. J. 371 (Pt 1): 131–142. doi:10.1042/BJ20021259. PMC 1223259. PMID 12492399.

This article incorporates text from the public domain Pfam and InterPro IPR010635

Transferases: sulfur-containing group (EC 2.8)

2.8.1: Sulfurtransferases	Thiosulfate sulfurtransferase Rhodanese 3-mercaptopyruvate sulfurtransferase thiosulfate—thiol sulfurtransferase tRNA sulfurtransferase thiosulfate—dithiol sulfurtransferase biotin synthase cysteine desulfurase

2.8.2: Sulfotransferases	Alcohol sulfotransferase Tyrosylprotein sulfotransferase Aryl sulfotransferase

2.8.3: CoA-transferases	Propionate CoA-transferase

2.8.4: Alkylthio	Coenzyme-B sulfoethylthiotransferase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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