Haber–Weiss reaction

The Haber–Weiss reaction generates •OH (hydroxyl radicals) from H₂O₂ (hydrogen peroxide) and superoxide (•O₂⁻). This reaction can occur in cells and is therefore a possible source for oxidative stress. The reaction is very slow, but is catalyzed by iron. The first step of the catalytic cycle involves reduction of ferric ion to ferrous:

Fe³⁺ + •O₂⁻ → Fe²⁺ + O₂

The second step is the Fenton reaction:

Fe²⁺ + H₂O₂ → Fe³⁺ + OH⁻ + •OH

Net reaction:

•O₂⁻ + H₂O₂ → •OH + OH⁻ + O₂

The reaction is named after Fritz Haber and his student Joseph Joshua Weiss.

References

• Koppenol, W.H. (2001). "The Haber-Weiss cycle – 70 years later". Redox Report. 6 (4): 229–234. doi:10.1179/135100001101536373. PMID 11642713. 
• Haber F., Weiss J. (1932). "Über die Katalyse des Hydroperoxydes (On the catalysis of hydroperoxide)". Naturwissenschaften. 20 (51): 948–950. Bibcode:1932NW.....20..948H. doi:10.1007/BF01504715.