HIST1H4L

HIST1H4L
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4H9O, 3WKJ, 3AYW, 3WA9, 5B0Z, 5AVB, 2CV5, 5AV5, 3AV2, 3WTP, 3AV1, 3AZK, 3X1V, 5AV8, 1F66, 4QUU, 3CFS, 4YYK, 4QUT, 3NQJ, 3A6N, 3W99, 5AVC, 2RS9, 3F9Z, 3QZT, 3QBY, 3W97, 4M38, 4YM6, 3CFV, 4HGA, 1EQZ, 2RJE, 3QZV, 1HQ3, 4H9P, 3AZL, 3AFA, 1TZY, 3UVY, 5CPK, 3JPX, 4U9W, 4N3W, 4YYJ, 4YYD, 4H9N, 4H9R, 3AZI, 4LD9, 3UVX, 3AZH, 5BNX, 4N4F, 1U35, 4YYG, 3O36, 2ARO, 5AV9, 4H9S, 3AZF, 3W98, 4GQB, 4H9Q, 5BNV, 3WAA, 3AZG, 3AZE, 2RNY, 1ZKK, 2QQS, 2LVM, 3X1T, 3AN2, 2KWO, 3QZS, 3F9W, 5FFW, 5CPJ, 3F9X, 3IJ1, 4YM5, 3AZJ, 4YY6, 3AZN, 2IG0, 4YYH, 4YYI, 5CPI, 3W96, 3R45, 2KWN, 3F9Y, 5AV6, 3AZM, 5BO0, 3X1S, 4QYD, 4KGC, 3UVW, 4YYN, 3X1U, 3UW9, 2F8N, 3NQU, 5B0Y, 4YYM, 5C3I, 4Z5T, 5B24, 5FA5, 4Z2M, 5E5A, 5FWE, 5B2I, 5B40, 5B2J, 5JA4, 5AY8, 4ZUX
Identifiers
Aliases	HIST1H4L, H4.k, H4/k, H4FK, histone cluster 1, H4l
External IDs	MGI: 4843992 HomoloGene: 136248 GeneCards: HIST1H4L
Gene ontology Molecular function • DNA binding • protein domain specific binding • histone binding • protein binding • protein heterodimerization activity • poly(A) RNA binding Cellular component • membrane • chromosome • protein complex • nucleoplasm • extracellular region • nuclear chromosome • nucleosome • extracellular exosome • nucleus • nuclear chromosome, telomeric region • extracellular matrix Biological process • telomere organization • cellular protein metabolic process • positive regulation of gene expression, epigenetic • protein heterotetramerization • negative regulation of megakaryocyte differentiation • CENP-A containing nucleosome assembly • DNA replication-dependent nucleosome assembly • chromatin silencing at rDNA • negative regulation of gene expression, epigenetic • DNA-templated transcription, initiation • DNA replication-independent nucleosome assembly • gene silencing by RNA • double-strand break repair via nonhomologous end joining • beta-catenin-TCF complex assembly • nucleosome assembly • telomere capping Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8368	319161
Ensembl	ENSG00000275126	ENSMUSG00000069305
UniProt	P62805	n/a
RefSeq (mRNA)	NM_003546	NM_175657
RefSeq (protein)	NP_001029249.1 NP_003486.1 NP_003529.1 NP_003530.1 NP_003531.1 NP_003532.1 NP_003533.1 NP_003534.1 NP_003535.1 NP_003536.1 NP_003537.1 NP_003539.1 NP_068803.1 NP_778224.1	n/a
Location (UCSC)	Chr 6: 27.87 – 27.87 Mb	Chr 13: 21.83 – 21.83 Mb
PubMed search	[1]	[2]
Wikidata

Histone H4 is a protein that in humans is encoded by the HIST1H4L gene.^[3][4][5][6]

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.^[6]

References

Further reading

PDB gallery
1aoi: COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT  1eqz: X-RAY STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 2.5 A RESOLUTION  1f66: 2.6 A CRYSTAL STRUCTURE OF A NUCLEOSOME CORE PARTICLE CONTAINING THE VARIANT HISTONE H2A.Z  1hq3: CRYSTAL STRUCTURE OF THE HISTONE-CORE-OCTAMER IN KCL/PHOSPHATE  1id3: CRYSTAL STRUCTURE OF THE YEAST NUCLEOSOME CORE PARTICLE REVEALS FUNDAMENTAL DIFFERENCES IN INTER-NUCLEOSOME INTERACTIONS  1kx3: X-Ray Structure of the Nucleosome Core Particle, NCP146, at 2.0 A Resolution  1kx4: X-Ray Structure of the Nucleosome Core Particle, NCP146b, at 2.6 A Resolution  1kx5: X-Ray Structure of the Nucleosome Core Particle, NCP147, at 1.9 A Resolution  1m18: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA  1m19: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA  1m1a: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA  1p34: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1p3a: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1p3b: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1p3f: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1p3g: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1p3i: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1p3k: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1p3l: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1p3m: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1p3o: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1p3p: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants  1s32: Molecular Recognition of the Nucleosomal 'Supergroove'  1tzy: Crystal Structure of the Core-Histone Octamer to 1.90 Angstrom Resolution  1u35: Crystal structure of the nucleosome core particle containing the histone domain of macroH2A  1zbb: Structure of the 4_601_167 Tetranucleosome  1zla: X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core  2aro: Crystal Structure Of The Native Histone Octamer To 2.1 Angstrom Resolution, Crystalised In The Presence Of S-Nitrosoglutathione  2cv5: Crystal structure of human nucleosome core particle  2f8n: 2.9 Angstrom X-ray structure of hybrid macroH2A nucleosomes  2fj7: Crystal structure of Nucleosome Core Particle Containing a Poly (dA.dT) Sequence Element  2hio: HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN  2hue: Structure of the H3-H4 chaperone Asf1 bound to histones H3 and H4  2io5: Crystal structure of the CIA- histone H3-H4 complex  2nzd: Nucleosome core particle containing 145 bp of DNA