H3K27me3

H3K27me3 is the trimethylated lysine residue at position 27 in the protein histone H3. H3K27me3 is known as a repressive mark because of its association with repression of gene expression. EZH2 protein of polycomb repressive complex 2 (PRC2) transfers the methyl group to H3K27.[1] and UTX in human removed the trimethylation in human[2]

References

  1. ↑ A, Kuzmichev (2002). "Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.". Genes Dev (15;16(22):2893-905.). PMID 12435631.
  2. ↑ T, Sengoku (2011). "Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A.". Genes Dev. 1;25(21):2266-77. PMID 22002947.
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