H1FOO

H1FOO
Identifiers
Aliases H1FOO, osH1, H1.8, H1oo, H1 histone family member O, oocyte specific
External IDs MGI: 2176207 HomoloGene: 51377 GeneCards: H1FOO
Orthologs
Species Human Mouse
Entrez

132243

171506

Ensembl

ENSG00000178804

ENSMUSG00000042279

UniProt

Q8IZA3

Q8VIK3

RefSeq (mRNA)

NM_001308262
NM_153833

NM_138311

RefSeq (protein)

NP_001295191.1
NP_722575.1

NP_612184.1

Location (UCSC) Chr 3: 129.54 – 129.55 Mb Chr 6: 115.94 – 115.95 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Histone H1oo is a protein that in humans is encoded by the H1FOO gene.[3][4]

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The protein encoded is a member of the histone H1 family. The related mouse gene is expressed only in oocytes.[4]

It incorporates into sperm chromatin after fertilisation.[5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (November 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  4. 1 2 "Entrez Gene: H1 histone family".
  5. Mizusawa Y, Kuji N, Tanaka Y, et al. (March 2010). "Expression of human oocyte-specific linker histone protein and its incorporation into sperm chromatin during fertilization". Fertil Steril. 93 (4): 1134–1141. doi:10.1016/j.fertnstert.2008.11.028. PMID 19147139.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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