Galactonolactone dehydrogenase
| L-galactonolactone dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.2.3 | ||||||||
| CAS number | 2603847 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
L-galactonolactone dehydrogenase (EC 1.3.2.3, galactonolactone dehydrogenase, L-galactono-gamma-lactone dehydrogenase, L-galactono-gamma-lactone:ferricytochrome-c oxidoreductase, GLDHase, GLDase) is an enzyme with systematic name L-galactono-1,4-lactone:ferricytochrome-c oxidoreductase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- (1) L-galactono-1,4-lactone + 2 ferricytochrome c L-ascorbate + 2 ferrocytochrome c + 2 H+
- (2) L-ascorbate + 2 ferricytochrome c L-dehydroascorbate + 2 ferrocytochrome c + 2 H+ (spontaneous)
This enzyme catalyses the final step in the biosynthesis of L-ascorbic acid in higher plants and in nearly all higher animals, except for primates and some birds.
References
- ↑ Mapson, L.W.; Breslow, E. (1957). "Properties of partially purified L-galactono-γ-lactone dehydrogenase". Biochem. J. 65: 29–29.
- ↑ Mapson, L.W.; Isherwood, F.A.; Chen, Y.T. (1954). "Biological synthesis of L-ascorbic acid: the conversion of L-galactono-γ-lactone into L-ascorbic acid by plant mitochondria". Biochem. J. 56 (1): 21–28. PMC 1269564
. PMID 13126087. - ↑ Isherwood, F.A.; Chen, Y.T.; Mapson, L.W. (1954). "Synthesis of L-ascorbic acid in plants and animals.". Biochem. J. 56 (1): 1–15. PMC 1269562. PMID 13126085.
- ↑ Ôba, K.; Ishikawa, S.; Nishikawa, M.; Mizuno, H.; Yamamoto, T. (1995). "Purification and properties of L-galactono-γ-lactone dehydrogenase, a key enzyme for ascorbic acid biosynthesis, from sweet potato roots". J. Biochem. (Tokyo). 117 (1): 120–124. PMID 7775377.
- ↑ Østergaard, J.; Persiau, G.; Davey, M.W.; Bauw, G.; Van Montagu, M. (1997). "Isolation of a cDNA coding for L-galactono-γ-lactone dehydrogenase, an enzyme involved in the biosynthesis of ascorbic acid in plants. Purification, characterization, cDNA cloning, and expression in yeast". J. Biol. Chem. 272 (48): 30009–30016. doi:10.1074/jbc.272.48.30009. PMID 9374475.
External links
- L-galactonolactone dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)
This article is issued from Wikipedia - version of the 5/19/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.