GZMB

GZMB
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
Aliases GZMB, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, granzyme B
External IDs HomoloGene: 108184 GeneCards: GZMB
Genetically Related Diseases
Vitiligo[1]
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

3002

n/a

Ensembl

ENSG00000100453

n/a

UniProt

P10144

n/a

RefSeq (mRNA)

NM_004131

n/a

RefSeq (protein)

NP_004122.2

n/a

Location (UCSC) Chr 14: 24.63 – 24.63 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Granzyme B is a serine protease that in humans is encoded by the GZMB gene.[3] Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.

CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.[4]

See also

References

  1. "Diseases that are genetically associated with GZMB view/edit references on wikidata".
  2. "Human PubMed Reference:".
  3. Dahl CA, Bach FH, Chan W, Huebner K, Russo G, Croce CM, Herfurth T, Cairns JS (May 1990). "Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14". Hum Genet. 84 (5): 465–70. doi:10.1007/bf00195821. PMID 2323780.
  4. "Entrez Gene: GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)".

Further reading

External links


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