GTF3C4

GTF3C4

Identifiers

GTF3C4, KAT12, TFIII90, TFIIIC290, TFIIIC90, TFIIICDELTA, TF3C-delta, general transcription factor IIIC subunit 4

External IDs

MGI: 2138937 HomoloGene: 8147 GeneCards: GTF3C4

Gene ontology
Molecular function	• histone acetyltransferase activity • transferase activity • DNA binding • enzyme activator activity • transferase activity, transferring acyl groups • protein binding
Cellular component	• transcription factor TFIIIC complex • nucleus • nucleoplasm
Biological process	• tRNA transcription from RNA polymerase III promoter • 5S class rRNA transcription from RNA polymerase III type 1 promoter • transcription initiation from RNA polymerase III promoter • transcription, DNA-templated • positive regulation of catalytic activity • transcription from RNA polymerase III promoter • histone acetylation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


9329


269252


ENSG00000125484


ENSMUSG00000035666


Q9UKN8


Q8BMQ2

RefSeq (mRNA)


NM_012204


NM_001166033 NM_172977

RefSeq (protein)


NP_036336.2


NP_001159505.1 NP_766565.2

Location (UCSC)

Chr 9: 132.67 – 132.69 Mb

Chr 2: 28.82 – 28.84 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

General transcription factor 3C polypeptide 4 is a protein that in humans is encoded by the GTF3C4 gene.^[3]^[4]

Interactions

GTF3C4 has been shown to interact with GTF3C2,^[3] GTF3C1,^[3] POLR3C^[3]^[5] and GTF3C5.^[3]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 3 4 5 Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
↑ "Entrez Gene: GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa".
↑ Hsieh YJ, Wang Z, Kovelman R, Roeder RG (Jul 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. PMC 84305. PMID 10373544.

Further reading

Dumay-Odelot H, Marck C, Durrieu-Gaillard S, Lefebvre O, Jourdain S, Prochazkova M, Pflieger A, Teichmann M (2007). "Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC". J. Biol. Chem. 282 (23): 17179–89. doi:10.1074/jbc.M611542200. PMID 17409385.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Hsieh YJ, Wang Z, Kovelman R, Roeder RG (1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. PMC 84305. PMID 10373544.
Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.

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