GDP-fucose protein O-fucosyltransferase 2
| protein O-fucosyltransferase 2 | |
|---|---|
| Identifiers | |
| Symbol | POFUT2 |
| Alt. symbols | C21orf80 |
| Entrez | 23275 |
| HUGO | 14683 |
| OMIM | 610249 |
| RefSeq | NM_133634 |
| UniProt | Q9Y2G5 |
| Other data | |
| Locus | Chr. 21 q22.3 |
GDP-fucose protein O-fucosyltransferase 2 (POFUT2) is an enzyme responsible for adding fucose sugars in O linkage to serine or threonine residues in Thrombospondin repeats.[1] The protein is an inverting glycosyltransferase, which means that the enzyme uses GDP-β-L-fucose as a donor substrate and transfers the fucose in O linkage to the protein producing fucose-α-O-serine/threonine.
Almost all glycosyltransferases reside in the Golgi apparatus. However, POFUT2 as well as the related enzyme POFUT1 have recently been shown to reside in the endoplasmic reticulum.
References
External links
- POFUT2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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