Chlorothiazide

Chlorothiazide
Clinical data
Trade names Diuril
AHFS/Drugs.com Monograph
MedlinePlus a682341
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration
Oral, IV
ATC code C03AA04 (WHO)
Legal status
Legal status
Pharmacokinetic data
Bioavailability low
Metabolism Nil
Biological half-life 45 to 120 minutes
Excretion Renal
Identifiers
CAS Number 58-94-6 YesY
PubChem (CID) 2720
IUPHAR/BPS 4835
DrugBank DB00880 YesY
ChemSpider 2619 YesY
UNII 77W477J15H YesY
KEGG D00519 YesY
ChEBI CHEBI:3640 YesY
ChEMBL CHEMBL842 YesY
ECHA InfoCard 100.000.368
Chemical and physical data
Formula C7H6ClN3O4S2
Molar mass 295.72 g/mol
3D model (Jmol) Interactive image
  (verify)

Chlorothiazide sodium (Diuril) is an organic compound used as a diuretic and as an antihypertensive.[1]

It is used both within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. Most often taken in pill form, it is usually taken orally once or twice a day. In the ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide (Lasix). Working in a separate mechanism than furosemide, and absorbed enterically as a reconstituted suspension administered through a nasogastric tube (NG tube), the two drugs potentiate one another.

It was discovered in 1957.[2]

Indications

Contraindications

Side effects

History

The Research team of Merck Sharp and Dohme Research Laboratories of Beyer, Sprague, Baer, and Novello created a new series of medications, the thiazide diuretics, which includes chlorothiazide. They won an Albert Lasker Special Award in 1975 for this work.[3]

References

  1. Ernst, Michael E.; Grimm, Richard H., Jr. "Thiazide diuretics: 50 years and beyond" Current Hypertension Reviews 2008, volume 4(4), pp. 256-265. doi:10.2174/157340208786241264
  2. Walker, S. R. (2012). Trends and Changes in Drug Research and Development. Springer Science & Business Media. p. 109. ISBN 9789400926592.
  3. http://www.laskerfoundation.org/awards/formaward.htm
This article is issued from Wikipedia - version of the 9/1/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.